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Titolo:
THE ROLE OF BETA-ADRENOCEPTOR BLOCKERS IN THE TREATMENT OF PSYCHIATRIC-DISORDERS
Autore:
BAILLY D;
Indirizzi:
CHU LILLE,ADDICT BEHAV UNIT,57 BLVD METZ F-59037 LILLE FRANCE
Titolo Testata:
CNS DRUGS
fascicolo: 2, volume: 5, anno: 1996,
pagine: 115 - 136
SICI:
1172-7047(1996)5:2<115:TROBBI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED AKATHISIA; CENTRAL-NERVOUS-SYSTEM; ORGANIC BRAIN DISEASE; INTERMITTENT EXPLOSIVE DISORDER; POSTTRAUMATIC STRESS DISORDER; ADRENERGIC-BLOCKING-DRUGS; RANDOMIZED CLINICAL-TRIAL; PLACEBO CONTROLLED TRIAL; LITHIUM-INDUCED TREMOR; ALCOHOL-WITHDRAWAL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
207
Recensione:
Indirizzi per estratti:
Citazione:
D. Bailly, "THE ROLE OF BETA-ADRENOCEPTOR BLOCKERS IN THE TREATMENT OF PSYCHIATRIC-DISORDERS", CNS DRUGS, 5(2), 1996, pp. 115-136

Abstract

Although beta-adrenoceptor blockers (in particular, propranolol) havebeen used in the treatment of psychiatric disorders for many years, their indications, extent of efficacy and place in therapy remain unclear. This overview assess the published reports on the use of these drugs in psychiatric disorders. It can be concluded that beta-adrenoceptor blockers may be helpful in the management of some forms of anxiety disorders, including performance anxiety and other types of situationalanxiety, especially when somatic symptoms are prominent. In the same way, alcohol (ethanol) withdrawal syndrome of moderate severity, antipsychotic-induced akathisia and lithium-induced tremor seem to be responsive to this drug class. Because of the fact that they are well tolerated, the use of beta-adrenoceptor blockers in these disorders should be considered whenever drug treatment is being contemplated. In contrast, the efficacy of high doses of beta-adrenoceptor blockers in schizophrenia remains unestablished. However, they may be of benefit in somepatients presenting with aggressive behaviour due to organic brain disease. Studies have shown a high rate of improvement in this condition, especially in patients who have previously failed to respond to other treatments. Finally, preliminary results suggest that beta-adrenoceptor blockers may be useful as adjunctive medication in the treatment of depression and chronic anxiety, but further investigations are needed in these areas of patient management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:43:57