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Titolo:
PLACENTAL CHANGES IN A FIRST-TRIMESTER MISSED ABORTION IN MATERNAL SYSTEMIC LUPUS-ERYTHEMATOSUS WITH ANTIPHOSPHOLIPID SYNDROME - A CASE-REPORT AND REVIEW OF THE LITERATURE
Autore:
NAYAR R; LAGE JM;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,DEPT PATHOL,4367 N HOSP,901 23RD ST NWWASHINGTON DC 20037 GEORGETOWN UNIV,MED CTR WASHINGTON DC 20007
Titolo Testata:
Human pathology
fascicolo: 2, volume: 27, anno: 1996,
pagine: 201 - 206
SICI:
0046-8177(1996)27:2<201:PCIAFM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICARDIOLIPIN ANTIBODIES; ACUTE ATHEROSIS; FETAL LOSS; ANTI-COAGULANT; ANTICOAGULANTS; PREGNANCY; CARDIOLIPIN; BINDING; BETA-2-GLYCOPROTEIN-I; THROMBOCYTOPENIA;
Keywords:
SYSTEMIC LUPUS ERYTHEMATOSUS; ANTIPHOSPHOLIPID SYNDROME; FIRST-TRIMESTER; DECIDUAL VASCULOPATHY; VILLOUS INFARCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
R. Nayar e J.M. Lage, "PLACENTAL CHANGES IN A FIRST-TRIMESTER MISSED ABORTION IN MATERNAL SYSTEMIC LUPUS-ERYTHEMATOSUS WITH ANTIPHOSPHOLIPID SYNDROME - A CASE-REPORT AND REVIEW OF THE LITERATURE", Human pathology, 27(2), 1996, pp. 201-206

Abstract

The placental lesions generally attributed to the effects of systemiclupus erythematosus (SLE) on the decidua and placental villi include decidual vasculopathy, placental infarcts and possibly intra-uterine growth retardation. The maternal decidual vessels in SLE show a lesion termed ''acute atherosis'' which is histologically similar to acute vascular rejection in a transplanted kidney. These changes can be so extensive as to result in complete vascular occlusion, decreased placental perfusion and resultant placental villous infarction. In curettings from products of conception in the first trimester, acute atherosis isa rare finding. We describe striking decidual vasculopathy and extensive villous infarction in a case of a first trimester missed abortion in a patient with SLE who had anticardiolipin antibodies (ACL), both immunoglobulin (IgG) and IgM, and lupus anticoagulant (LA) in her serum. To the best of our knowledge, this is the first report of acute atherosis and villous infarction in a first trimester placenta in association with SLE and/or ACL and LA. Pathologists should be aware of these changes and alert clinicians to the possibility of SLE or antiphospholipid and/or anticardiolipin antibodies. Copyright (C) 1996 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:13:16