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Titolo:
GENETIC AND ENVIRONMENTAL-INFLUENCES ON INSULIN LEVELS AND THE INSULIN-RESISTANCE SYNDROME - AN ANALYSIS OF WOMEN TWINS
Autore:
MAYER EJ; NEWMAN B; AUSTIN MA; ZHANG D; QUESENBERRY CP; EDWARDS K; SELBY JV;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI,MED CTR BLVD WINSTON SALEM NC 27157 UNIV N CAROLINA,SCH PUBL HLTH,DEPT EPIDEMIOL CHAPEL HILL NC 00000 UNIV WASHINGTON,DEPT EPIDEMIOL,SCH PUBL HLTH & COMMUNITY MED SEATTLE WA 98195 KAISER PERMANENTE MED CARE PROGRAM OAKLAND CA 00000
Titolo Testata:
American journal of epidemiology
fascicolo: 4, volume: 143, anno: 1996,
pagine: 323 - 332
SICI:
0002-9262(1996)143:4<323:GAEOIL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; DEPENDENT DIABETES-MELLITUS; IMPAIRED GLUCOSE-TOLERANCE; CORONARY HEART-DISEASE; BODY-FAT DISTRIBUTION; PHYSICAL-ACTIVITY; PIMA-INDIANS; RISK-FACTORS; HYPERTRIGLYCERIDEMIA; TRIGLYCERIDES;
Keywords:
BLOOD PRESSURE; GENES; INSULIN; INSULIN RESISTANCE; LIPOPROTEINS; OBESITY; PLASMA; TWINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Mayer et al., "GENETIC AND ENVIRONMENTAL-INFLUENCES ON INSULIN LEVELS AND THE INSULIN-RESISTANCE SYNDROME - AN ANALYSIS OF WOMEN TWINS", American journal of epidemiology, 143(4), 1996, pp. 323-332

Abstract

Multiple factors may determine insulin resistance and the insulin resistance syndrome. The contributions of genes and environment to the distribution of fasting insulin levels and to the associations of fasting insulin with elements of the syndrome were evaluated in the second examination of the Kaiser Permanente Women Twins Study (Oakland, California, 1989-1990). Subjects included 556 white women (165 monozygous twin pairs, 113 dizygous pairs; 455 women with normal glucose tolerance,75 with impaired glucose tolerance, and 26 with non-insulin-dependentdiabetes by World Health Organization criteria). The intraclass correlation coefficients for log fasting insulin for monozygous and dizygous twin pairs were 0.64 and 0.40, respectively. After adjustment for age, behavioral factors, and body mass index, the estimated classic heritability was 0.53 (p = 0.003). Commingling analysis of fasting insulinindicated the presence of four distributions (P < 0.001), consistent with at least one, and perhaps two, genes influencing this trait. In an unmatched multiple regression model among women from monozygous twinpairs only, log fasting insulin was independently associated with body mass index (p < 0.0001), waist/hip ratio (p = 0.02), and glucose intolerance (p = 0.04), but not with triglycerides, high density lipoprotein cholesterol, or hypertension. After removal of genetic influences by analysis of monozygous intrapair differences, only body mass index (p < 0.0001) remained independently related to fasting insulin. The authors conclude that, in addition to significant genetic influences on fasting insulin, environmental or behavioral factors (particularly nongenetic variation in obesity) are important determinants of fasting insulin and the insulin resistance syndrome. Am J Epidemiol 1996;143:323-32.

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Documento generato il 04/12/20 alle ore 18:16:34