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Titolo:
THE BENEFICIAL EFFECT OF BPC-157, A 15 AMINO-ACID PEPTIDE BPC FRAGMENT, ON GASTRIC AND DUODENAL LESIONS INDUCED BY RESTRAINT STRESS, CYSTEAMINE AND 96-PERCENT ETHANOL IN RATS - A COMPARATIVE-STUDY WITH H-2-RECEPTOR ANTAGONISTS, DOPAMINE PROMOTORS AND GUT PEPTIDES
Autore:
SIKIRIC P; SEIWERTH S; GRABAREVIC Z; PETEK M; RUCMAN R; TURKOVIC B; ROTKVIC I; JAGIC V; DUVNJAK M; MISE S; DJACIC S; SEPAROVIC J; VELJACA M; SALLMANI A; BANIC M; BRKIC T;
Indirizzi:
UNIV ZAGREB,FAC MED,DEPT PHARMACOL,CDD,SALATA 11,POB 916 ZAGREB 41000CROATIA UNIV ZAGREB,FAC MED & VET,CDD ZAGREB CROATIA
Titolo Testata:
Life sciences
fascicolo: 5, volume: 54, anno: 1994,
pagine: 63 - 68
SICI:
0024-3205(1994)54:5<63:TBEOBA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGONISTS;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
P. Sikiric et al., "THE BENEFICIAL EFFECT OF BPC-157, A 15 AMINO-ACID PEPTIDE BPC FRAGMENT, ON GASTRIC AND DUODENAL LESIONS INDUCED BY RESTRAINT STRESS, CYSTEAMINE AND 96-PERCENT ETHANOL IN RATS - A COMPARATIVE-STUDY WITH H-2-RECEPTOR ANTAGONISTS, DOPAMINE PROMOTORS AND GUT PEPTIDES", Life sciences, 54(5), 1994, pp. 63-68

Abstract

The protection of stomach and duodenum in conjecture with anti-inflammatory effect was demonstrated for a novel 15 amino acid peptide, coded BPC 157, a fragment of the recently discovered gastric juice peptideBPC. BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment). Only BPC 157 regimens were consistently effective in all of the tested models. On the other hand, bromocriptine, amantadine, famotidine, cimetidine and somatostatin were ineffective (restraint stress). A dose-dependent protection (cysteamine) and/or partial positive effect (related to treatment conditions) (ethanol), was obtained with glucagon, NPY and secretin whereas CCK/26-30/ was not effective. Based on Monastral blue studies BPC 157 beneficial effect appears to be related to a strong endothelial protection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:01:00