Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AIRWAY INTERLEUKIN-8 IN ELDERLY PATIENTS WITH BACTERIAL LOWER RESPIRATORY-TRACT INFECTIONS
Autore:
PONGLERTNAPAGORN P; OISHI K; IWAGAKI A; SONODA F; WATANABE K; NAGATAKE T; MATSUSHIMA K; MATSUMOTO K;
Indirizzi:
NAGASAKI UNIV,INST TROP MED,DEPT INTERNAL MED,1-12-4 SAKAMOTO MACHI NAGASAKI 852 JAPAN NAGASAKI UNIV,INST TROP MED,DEPT INTERNAL MED NAGASAKI 852 JAPAN KANAZAWA UNIV,CANC RES INST,DEPT PHARMACOL KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Microbiology and immunology
fascicolo: 2, volume: 40, anno: 1996,
pagine: 177 - 182
SICI:
0385-5600(1996)40:2<177:AIIEPW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHIL CHEMOTACTIC FACTOR; PSEUDOMONAS-AERUGINOSA; MONOCLONAL-ANTIBODIES; PNEUMONIA; LIPOPOLYSACCHARIDE; MICE;
Keywords:
INTERLEUKIN-8; BACTERIAL LOWER RESPIRATORY TRACT INFECTIONS; OPSONOPHAGOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Ponglertnapagorn et al., "AIRWAY INTERLEUKIN-8 IN ELDERLY PATIENTS WITH BACTERIAL LOWER RESPIRATORY-TRACT INFECTIONS", Microbiology and immunology, 40(2), 1996, pp. 177-182

Abstract

We investigated the interleukin-8 (IL-8) levels and neutrophil numbers in the sputum of 9 elderly patients with lower respiratory tract infections, including Pseudomonas aeruginosa infection, before and after treatment with various antimicrobial agents, The IL-8 levels in sputumsupernatants and the neutrophil numbers in sputum smears from 9 patients decreased significantly after the elimination of the causative respiratory pathogens. We also demonstrated that human recombinant IL-8 at a range of 6.25-25 ng/ml significantly enhanced opsonophagocytic killing of P. aeruginosa immunotype-1 strain by human neutrophils in the presence of a serotype-specific anti-lipopolysaccharide monoclonal antibody and fresh normal human serum, These data suggest that the level of IL-8 production in the airways of patients with lower respiratory tract infections is dependent on bacterial densities, and indicate the important role of IL-8 not only in neutrophil migration but also in opsonophagocytic killing of bacteria in the lower respiratory tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:16:02