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Titolo:
MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF THE PENTON BASE GENES OF TYPE-II AVIAN ADENOVIRUSES
Autore:
SURESH M; STCYR S; SHARMA JM;
Indirizzi:
UNIV MINNESOTA,COLL VET MED,DEPT VET PATHOBIOL,1971 COMMON WEALTH AVEST PAUL MN 55108 UNIV MINNESOTA,COLL VET MED,DEPT VET PATHOBIOL ST PAUL MN 55108 UNIV MINNESOTA,INST HUMAN GENET MINNEAPOLIS MN 55455
Titolo Testata:
Virus research
fascicolo: 2-3, volume: 39, anno: 1995,
pagine: 289 - 297
SICI:
0168-1702(1995)39:2-3<289:MASOTP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMORRHAGIC ENTERITIS; PROTEINS; VIRUS; POLYPEPTIDES; INTEGRINS; ADHESION; TURKEYS; FAMILY;
Keywords:
TYPE II AVIAN ADENOVIRUS; HEMORRHAGIC ENTERITIS VIRUS; PENTON BASE; GENE; LDV MOTIF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M. Suresh et al., "MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF THE PENTON BASE GENES OF TYPE-II AVIAN ADENOVIRUSES", Virus research, 39(2-3), 1995, pp. 289-297

Abstract

We describe here the identification of the penton base gene of hemorrhagic enteritis virus (HEV), a type II avian adenovirus, in a 2477-base pair (bp)-EcoRI fragment of the viral DNA by sequence analysis. Identification is based on an extensive amino acid homology between the HEV-open reading frame and the penton base of a fowl adenovirus (FAV-10)and various human adenoviruses. The 1344 bp-penton base gene of HEV encodes a 448-amino acid polypeptide of molecular weight of 50,843 Da. The nucleotide sequences of penton base genes of HEV and marble spleendisease virus (MSDV) are identical. The HEV penton base lacks the RGDmotif, present in most human adenoviruses (Ad2, Ad3, Ad4, and Ad 12) suggesting that HEV may not use alpha v integrins to gain entry into host cells. Further sequence analysis revealed the presence of a Leu-Asp-Val (LDV) motif in the HEV penton base amino acid sequence similar to most of the human adenoviruses. LDV motif on the fibronectin has been shown to interact with the alpha 4 beta 1 integrins on cells, which includes lymphocytes and monocytes. The presence of LDV motif in the penton base of HEV implicates the involvement of alpha 4 beta 1 integrins in the viral internalization into host cells.

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Documento generato il 13/07/20 alle ore 09:48:21