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Titolo:
EXOGENOUS SEX-HORMONE USE, CORRELATES OF ENDOGENOUS HORMONE LEVELS, AND THE INCIDENCE OF HISTOLOGIC TYPES OF SARCOMA OF THE UTERUS
Autore:
SCHWARTZ SM; WEISS NS; DALING JR; GAMMON MD; LIFF JM; WATT J; LYNCH CF; NEWCOMB PA; ARMSTRONG BK; THOMPSON WD;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,DIV PUBL HLTH SCI,PROGRAM EPIDEMIOL,1124COLUMBIA ST,MP-381 SEATTLE WA 98104 UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,DEPT EPIDEMIOL SEATTLE WA 98195 COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL NEW YORK NY 00000 EMORY UNIV,SCH PUBL HLTH,DIV EPIDEMIOL ATLANTA GA 00000 QUEEN ELIZABETH II MED CTR,NH & MRC RES UNIT EPIDEMIOL & PREVENT MED NEDLANDS WA AUSTRALIA UNIV IOWA,DEPT PREVENT MED & ENVIRONM HLTH IOWA CITY IA 52242 UNIV WISCONSIN,WISCONSIN CLIN CANC CTR MADISON WI 53792 AUSTRALIAN INST HLTH & WELFARE CANBERRA ACT AUSTRALIA UNIV SO MAINE,DEPT APPL MED SCI PORTLAND ME 04103
Titolo Testata:
Cancer
fascicolo: 4, volume: 77, anno: 1996,
pagine: 717 - 724
SICI:
0008-543X(1996)77:4<717:ESUCOE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOMETRIAL CANCER RISK; BODY-FAT DISTRIBUTION; UTERINE FIBROIDS; MULLERIAN TUMORS; ADIPOSE-TISSUE; WOMEN; SURVIVAL; EPIDEMIOLOGY; POPULATION; OBESITY;
Keywords:
UTERINE NEOPLASMS; HORMONES; SARCOMA; SMOKING; OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Schwartz et al., "EXOGENOUS SEX-HORMONE USE, CORRELATES OF ENDOGENOUS HORMONE LEVELS, AND THE INCIDENCE OF HISTOLOGIC TYPES OF SARCOMA OF THE UTERUS", Cancer, 77(4), 1996, pp. 717-724

Abstract

BACKGROUND, We analyzed data from a population-based, multi-center, case-control study to determine whether the occurrence of histologic types of uterine sarcoma is related to exogenous hormone use and/or to two correlates of endogenous estrogens: excess weight and cigarette smoking. METHODS, One hundred sixty-seven women with newly-diagnosed uterine sarcoma (56 leiomyosarcoma, 85 mixed mullerian tumors, and 26 endometrial stromal sarcomas) were interviewed by telephone regarding possible risk factors for these neoplasms. For comparison, 208 women identified at random from the general population of the study areas were interviewed as controls. RESULTS. Use of oral contraceptives was positively associated with the risk of leiomyosarcoma (odds ratios [OR] = 1.7, 95% confidence interval [CI] = 0.7, 4.1), primarily among women who last used these medications 15 or more years prior to diagnosis. Use of noncontraceptive estrogens was directly associated with the risk of mixed mullerian tumors, but only among recent and long-term users of these medications. Women in the highest quantile of body mass index (greater than or equal to 27.5 kg/m(2)) one year prior to diagnosis were at increased risk of each type of uterine sarcoma (leiomyosarcoma, OR = 2.5, 95% CI = 1.1, 5.7; mixed mullerian tumors, OR = 2.9, 95% CI = 1.3, 6.7; stromal sarcoma, OR = 3.5, 95% CI = 1.1, 10.9). Women who hadever smoked cigarettes were at reduced risk of leiomyosarcoma (OR = 0.6, 95% CI = 0.3, 1.1) and stromal sarcoma (OR = 0.5, 95% CI = 0.2, 1.2), but the relationship was not more pronounced among heavy smokers; no association with smoking was observed with mixed mullerian tumors. CONCLUSIONS. Several of these findings parallel those from studies of endometrial carcinoma, and may indicate a role for unopposed estrogen in the etiology of histologic types of uterine sarcoma. (C) 1996 American Cancer Society.

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Documento generato il 25/11/20 alle ore 07:05:07