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Titolo:
FAMINE, FIBER, FATTY-ACIDS, AND FAILED COLONIC ABSORPTION - DOES FIBER FERMENTATION AMELIORATE DIARRHEA
Autore:
ROEDIGER WEW;
Indirizzi:
UNIV ADELAIDE,QUEEN ELIZABETH HOSP,DEPT SURG,CELL PHYSIOL LAB WOODVILLE SA 5011 AUSTRALIA
Titolo Testata:
JPEN. Journal of parenteral and enteral nutrition
fascicolo: 1, volume: 18, anno: 1994,
pagine: 4 - 8
SICI:
0148-6071(1994)18:1<4:FFFAFC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL ELECTROLYTE TRANSPORT; RAT COLON; CARBONIC-ANHYDRASE; ION-TRANSPORT; CELL-PROLIFERATION; SODIUM-ABSORPTION; DIVERSION COLITIS; DIETARY FIBER; STARVATION; MALNUTRITION;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
W.E.W. Roediger, "FAMINE, FIBER, FATTY-ACIDS, AND FAILED COLONIC ABSORPTION - DOES FIBER FERMENTATION AMELIORATE DIARRHEA", JPEN. Journal of parenteral and enteral nutrition, 18(1), 1994, pp. 4-8

Abstract

The salvage function of the colon for absorption of unabsorbed sodiumand water from the jejunum and ileum depends upon the metabolic integrity of colonic epithelial cells maintained by luminal short-chain fatty acids. With the depletion of luminal short-chain fatty acids under conditions of starvation, metabolic compensation from vascular substrates is incomplete. Loss of luminal short-chain fatty acids diminishes cell membrane integrity and causes secretion by colonic epithelial cells, leading to starvation diarrhea. Because sodium absorption is dependent upon CO2 production from n-butyrate, no compensatory absorption occurs during starvation. Under conditions in which luminal short-chainfatty acids are depleted, dietary fiber is useful as a low osmolalityfood constituent and for renewal of short-chain fatty acid levels by bacterial fermentation. The ''antisecretory'' effect of dietary fiber depends on the degree of the preexisting depletion of short-chain fatty acids and the methodology used to assess absorptive function. Dietary fiber has not been found harmful in refeeding starvation victims forwhom it is an essential food constituent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:25:03