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Titolo:
CISPLATIN NEPHROTOXICITY AND PROTECTION BY SILIBININ
Autore:
GAEDEKE J; FELS LM; BOKEMEYER C; MENGS U; STOLTE H; LENTZEN H;
Indirizzi:
HANNOVER MED SCH,DIV NEPHROL,KONSTANTY GUTSCHOW STR 8 D-30625 HANNOVER GERMANY HANNOVER MED SCH,DIV NEPHROL D-30625 HANNOVER GERMANY SYSTA BIOMED GBM,DIV MOLEC EPIDEMIOL & NONINVAS DIAGNOST BOCHUM BAD OEYNHAUSEN GERMANY MADAUS AG COLOGNE GERMANY HANNOVER MED SCH,DEPT HEMATOL ONCOL HANNOVER GERMANY
Titolo Testata:
Nephrology, dialysis, transplantation
fascicolo: 1, volume: 11, anno: 1996,
pagine: 55 - 62
SICI:
0931-0509(1996)11:1<55:CNAPBS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL TUBULE CELLS; LIPID-PEROXIDATION; INDUCED HYPOMAGNESEMIA; RATS; TOXICITY; GLUCONEOGENESIS; ANTIOXIDANTS; FLAVONOIDS; ENZYMES;
Keywords:
NEPHROTOXICITY; NEPHROPROTECTION; CISPLATIN; SILIBININ; GLOMERULUS; TUBULAR APPARATUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J. Gaedeke et al., "CISPLATIN NEPHROTOXICITY AND PROTECTION BY SILIBININ", Nephrology, dialysis, transplantation, 11(1), 1996, pp. 55-62

Abstract

Background. The anticancer drug cisplatin is known to have toxic side-effects on different segments of the nephron. The flavonoid silibininhas previously been shown to be protective in models of hepatotoxicity. The aim of the present study was to evaluate, whether silibinin canalso ameliorate alterations in renal glomerular and tubular function and tubular morphology induced by cisplatin. Methods. In a rat model renal damage was induced by a single injection of cisplatin (5 mg/kg body weight). The protective effects of silibinin were studied in rats that received the flavonoid (200 mg/kg body weight, i.v.) 1 h prior to the administration of cisplatin. Kidney function was monitored by analysing urinary markers of glomerular and tubular function over a periodof 11 days. Animals of a second group, with identical treatment, weresacrificed 4 days after drug application for an evaluation of tubularmorphology at the light-microscopical level. Results. Administration of cisplatin caused a decline in kidney function within a day following treatment. Symptoms observed were for example decreases in creatinine clearance and increases in proteinuria, in the urinary activity of the proximal tubular enzymes alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase and in renal magnesium wasting. The effects of cisplatin on creatinine clearance and proteinuria were totally prevented by a pretreatment of the animals with silibinin. Impairment of proximal tubular function was ameliorated, that is enzymuria and magnesium wasting was less pronounced. Silibinin alone had no effect on kidney function. Treatment with silibinin distinctly diminished morphological alterations observed in the S-3-segment of the proximal tubule 4 days aftercisplatin administration. Conclusions. The effects of cisplatin on glomerular and proximal tubular function as well as proximal tubular morphology could totally or partly be ameliorated by silibinin. It is concluded that silibinin can act as a nephroprotectant and it is suggested that it could have beneficial effects on the kidney in clinical settings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:41:44