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Titolo:
CHANGES OF THE MUCOSAL N3 AND N6 FATTY-ACID STATUS OCCUR EARLY IN THECOLORECTAL ADENOMA-CARCINOMA SEQUENCE
Autore:
FERNANDEZBANARES F; ESTEVE M; NAVARRO E; CABRE E; BOIX J; ABADLACRUZ A; KLAASSEN J; PLANAS R; HUMBERT P; PASTOR C; GASSULL MA;
Indirizzi:
HOSP UNIV GERMANS TRIAS I PUJOL,DEPT GASTROENTEROL,RES UNIT,CARRETERACANYET S-N E-08916 BADALONA CATALUYNA SPAIN HOSP UNIV GERMANS TRIAS I PUJOL,DEPT GASTROENTEROL,RES UNIT E-08916 BADALONA CATALUYNA SPAIN HOSP UNIV GERMANS TRIAS I PUJOL,DEPT BIOCHEM E-08916 BADALONA CATALUYNA SPAIN
Titolo Testata:
Gut
fascicolo: 2, volume: 38, anno: 1996,
pagine: 254 - 259
SICI:
0017-5749(1996)38:2<254:COTMNA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED COLON CARCINOGENESIS; PROTEIN-KINASE-C; F344 RATS; FISH-OIL; CELL-PROLIFERATION; ARACHIDONIC-ACID; HEALTHY-SUBJECTS; TUMOR PROMOTION; CANCER; OMEGA-3-FATTY-ACIDS;
Keywords:
FATTY ACID COMPOSITION; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; FISH OIL; COLON CARCINOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
F. Fernandezbanares et al., "CHANGES OF THE MUCOSAL N3 AND N6 FATTY-ACID STATUS OCCUR EARLY IN THECOLORECTAL ADENOMA-CARCINOMA SEQUENCE", Gut, 38(2), 1996, pp. 254-259

Abstract

Despite data favouring a role of dietary fat in colonic carcinogenesis, no study has focused on tissue n3 and n6 fatty acid (FA) status in human colon adenoma-carcinoma sequence. Thus, FA profile was measured in plasma phospholipids of patients with colorectal cancer (n=22), sporadic adenoma (n=27), and normal colon (n=12) (control group). Additionally, mucosal FAs were assessed in both diseased and normal mucosa ofcancer (n=15) and adenoma (n=21) patients, and from normal mucosa of controls (n=8). There were no differences in FA profile of both plasmaphospholipids and normal mucosa, between adenoma and control patients. There were considerable differences, however, in FAs between diseased and paired normal mucosa of adenoma patients, with increases of linolenic (p=0.02), dihomogammalinolenic (p=0.014), and eicosapentaenoic (p=0.012) acids, and decreases of alpha linolenic (p=0 001) and arachidonic (p=0.02) acids in diseased mucosa. A stepwise reduction of eicosapentaenoic acid concentrations in diseased mucosa from benign adenoma to the most advanced colon cancer was seen (p=0 009). Cancer patients showed lower alpha linolenate (p=0.002) and higher dihomo gammalinolenate (p=0.003) in diseased than in paired normal mucosa. In conclusion changes in tissue n3 and n6 FA status might participate in the early phases of the human colorectal carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:10:10