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Titolo:
IS CONTROL OF DISTRIBUTION OF LIPOSOMES BETWEEN TUMORS AND BONE-MARROW POSSIBLE
Autore:
NAGAYASU A; UCHIYAMA K; NISHIDA T; YAMAGIWA Y; KAWAI Y; KIWADA H;
Indirizzi:
UNIV TOKUSHIMA,FAC PHARMACEUT SCI,1-78-1 SHOMACHI TOKUSHIMA 770 JAPAN UNIV TOKUSHIMA,FAC PHARMACEUT SCI TOKUSHIMA 770 JAPAN TAISHO PHARMACEUT CO LTD TOKUSHIMA 77101 JAPAN
Titolo Testata:
Biochimica et biophysica acta. Biomembranes
fascicolo: 1, volume: 1278, anno: 1996,
pagine: 29 - 34
SICI:
0005-2736(1996)1278:1<29:ICODOL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE UNILAMELLAR LIPOSOMES; LIPID-COMPOSITION; CIRCULATION TIME; SERUM OPSONINS; INVIVO; SIZE; MICE; OPSONOPHAGOCYTOSIS; DOXORUBICIN; MACROPHAGES;
Keywords:
LIPOSOME; DISTRIBUTION; SIZE; MEMBRANE FLUIDITY; TUMOR; BONE MARROW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Nagayasu et al., "IS CONTROL OF DISTRIBUTION OF LIPOSOMES BETWEEN TUMORS AND BONE-MARROW POSSIBLE", Biochimica et biophysica acta. Biomembranes, 1278(1), 1996, pp. 29-34

Abstract

The objective of this study is to clarify to what extent the accumulation of liposomes from the blood into the tumor and bone marrow can becontrolled by liposome size and membrane fluidity. Liposomes with different diameters (50-400 nm) and different membrane fluidity were prepared from hydrogenated egg phosphatidylcholine (HEPC) or egg phosphatidylcholine (EPC), cholesterol (Ch) and dicetylphosphate in various molar ratios, These liposomes were injected intravenously into rats bearing Yoshida sarcoma, and the ratios of the accumulation of liposomes inthe tumor to those in the bone marrow, liver and spleen were compared. The tumor-to-bone marrow accumulation ratio increased with the decrease in liposome size from 400 to 50 nm, This ratio was greater than those for the liver and spleen at all sizes. Although tumor-to-liver accumulation ratios of 50- and 100-nm HEPC-containing liposomes were higher than those of EPC-containing liposomes, no obvious difference in tumor-to-bone marrow or tumor-to-spleen accumulation ratios was found between these liposomes, Tumor-to-bone marrow accumulation ratio of HEPC-containing liposomes increased remarkably with the decrease in Ch content from 40 to 30 or 20 mol% compared with ratios for the liver and spleen. Interestingly, the tumor uptake clearance of liposomes of the same size was constant regardless of their membrane fluidity. These findings show that the increases in these accumulation ratios are due to their decreased uptake clearance by the bone marrow. Furthermore, the uptake of 50-nm HEPC-containing liposomes by the bone marrow was specifically inhibited by preinjection of other liposomes, but not when they were exposed in advance to in vivo components. These observations suggest the involvement of in vivo component(s) in the uptake of these liposomes by the bone marrow. We conclude that small HEPC-liposomes with low Ch content show their significantly decreased uptake by the bonemarrow due to their decreased recognition by this tissue.

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Documento generato il 22/09/20 alle ore 10:12:50