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Titolo:
EFFECTS OF AN ANTIOXIDANT IN A RABBIT MODEL OF TOURNIQUET-INDUCED SKELETAL-MUSCLE ISCHEMIA-REPERFUSION INJURY
Autore:
MOHLER LR; PEDOWITZ RA; OHARA WM; OYAMA BK; LOPEZ MA; GERSHUNI DH;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT ORTHOPAED SURG SAN DIEGO CA 92161 VET ADM MED CTR SAN DIEGO CA 92161
Titolo Testata:
The Journal of surgical research
fascicolo: 1, volume: 60, anno: 1996,
pagine: 23 - 28
SICI:
0022-4804(1996)60:1<23:EOAAIA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT LIPID-PEROXIDATION; REACTIVE OXYGEN METABOLITES; FREE-RADICAL SCAVENGERS; INDUCED NERVE ISCHEMIA; 21-AMINOSTEROID U74006F; PNEUMATIC TOURNIQUET; TIRILAZAD MESYLATE; TISSUE-INJURY; POSTISCHEMIC REPERFUSION; STRIATED-MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
L.R. Mohler et al., "EFFECTS OF AN ANTIOXIDANT IN A RABBIT MODEL OF TOURNIQUET-INDUCED SKELETAL-MUSCLE ISCHEMIA-REPERFUSION INJURY", The Journal of surgical research, 60(1), 1996, pp. 23-28

Abstract

The purpose of this study was to evaluate the effects of U74006F, a new antioxidant, on isometric contractile function after tourniquet-induced ischemia-reperfusion injury. Twenty-six NZW rabbits underwent either 2 or 4 hr of thigh tourniquet compression. Animals were randomizedto receive U74006F or an equal volume of its citrate vehicle. When tibialis anterior function was tested 2 days later, there was no difference between treatment groups in peak tension, rate of force production, contraction time, half relaxation time, or resistance to fatigue. The use of U74006F failed to improve functional outcome in this model ofischemia-reperfusion injury. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 11:10:11