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Titolo:
LOCALIZATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR MESSENGER-RNA INTHE ADULT-MOUSE BRAIN
Autore:
MASOS T; MISKIN R;
Indirizzi:
WEIZMANN INST SCI,DEPT BIOCHEM IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT BIOCHEM IL-76100 REHOVOT ISRAEL
Titolo Testata:
Molecular brain research
fascicolo: 1-2, volume: 35, anno: 1996,
pagine: 139 - 148
SICI:
0169-328X(1996)35:1-2<139:LOUPMI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; NEURONAL GROWTH; MESSENGER-RNA; CELL-SURFACE; RAT-BRAIN; TISSUE; MIGRATION; RECEPTOR; SYSTEM; DEGRADATION;
Keywords:
PLASMINOGEN ACTIVATOR; UROKINASE; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; UPA MESSENGER-RNA LOCALIZATION IN THE MOUSE BRAIN; IN SITU HYBRIDIZATION; SUBICULUM; ENTORHINAL CORTEX; PARIETAL CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
T. Masos e R. Miskin, "LOCALIZATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR MESSENGER-RNA INTHE ADULT-MOUSE BRAIN", Molecular brain research, 35(1-2), 1996, pp. 139-148

Abstract

Urokinase-type plasminogen activator (uPA) is an inducible serine protease, secreted by a variety of cell types, that functions in fibrinolysis and has been implicated also in events such as cell migration andtissue remodeling and repair. To explore the role of uPA in the adultbrain, we have now screened the whole mouse brain for cells expressing the uPA gene through in situ hybridization using S-35-complementary RNA. uPA mRNA was visualized predominantly in three regions: (1) the subicular complex, (2) the entorhinal cortex, (3) the parietal cortex, where the signal was somewhat lower and confined to layers IV and VI. Weaker signals were seen in the basolateral nucleus of the amygdala and in the anterodorsal thalamic nucleus, and also in the hilus of the dentate gyrus where labeling was slightly over background. Cells exhibiting uPA mRNA signaling were large neurons according to morphological criteria. These results support the view of uPA being involved in neuronal functions of the adult brain, specifically in the hippocampal formation and the parietal cortex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:56:10