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Titolo:
INDUCTION OF HEAT-SHOCK PROTEIN IN CARDIAC ALLOGRAFT-REJECTION - A CYCLOSPORINE-SUPPRESSIBLE RESPONSE
Autore:
DAVIS EA; WANG BH; STAGG CA; BALDWIN WM; BAUMGARTNER WA; SANFILIPPO F; UDELSMAN R;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DIV ENDOCRINE & ONCOL SURG,DEPT SURG,600 NWOLFE ST BALTIMORE MD 21287 JOHNS HOPKINS UNIV,SCH MED,DIV ENDOCRINE & ONCOL SURG,DEPT SURG BALTIMORE MD 21287 JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL BALTIMORE MD 21287
Titolo Testata:
Transplantation
fascicolo: 2, volume: 61, anno: 1996,
pagine: 279 - 284
SICI:
0041-1337(1996)61:2<279:IOHPIC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE-BINDING-PROTEIN; ANTIGEN PRESENTATION; EXPRESSION; STRESS; ATHEROSCLEROSIS; LOCALIZATION; ABSENCE; PLAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Davis et al., "INDUCTION OF HEAT-SHOCK PROTEIN IN CARDIAC ALLOGRAFT-REJECTION - A CYCLOSPORINE-SUPPRESSIBLE RESPONSE", Transplantation, 61(2), 1996, pp. 279-284

Abstract

The cellular response to a wide variety of stresses results in the synthesis of a family of proteins termed heat shock proteins (HSPs), To determine if acute allograft rejection could induce these proteins in a transplanted graft, we examined the HSP response to acute cardiac allograft rejection and analyzed the effect of immunosuppression upon this response. Donor hearts obtained from either Lewis (LEW) or ACI ratswere heterotopically transplanted in recipient LEW rats, There were 4experimental groups: untreated isografted (LEW to LEW) animals (n=14), untreated allografted (ACI to LEW) animals (n=14), cyclosporine-treated (10 mg/kg SQ/day) isografted animals (n=12), and cyclosporine-treated allografted animals (n=12), Animals were sacrificed on posttransplantation day 2, 4, or 6 (time of rejection for untreated allografts); n=4-5 for each time point per group, At these times tissue obtained from the transplanted heart was examined histologically and analyzed forHSP72 by quantitative Northern and Western blots, The level of HSP72 in the untreated allografts progressively increased between 2, 4, and 6 days posttransplantation and was significantly greater than that of the untreated isografts at;all time points, The HSP72 response in cyclosporine-treated allografts was significantly reduced at 4 and 6 days posttransplantation compared with the untreated allografts, In contrast, there was no difference in the HSP response in treated versus untreated isografts. Additionally, there was no difference in HSP levels incyclosporine-treated isografts and allografts. These findings demonstrate that HSP expression in the transplanted heart correlates directlywith the evolution of acute allograft rejection, and that immunosuppressive therapy inhibits the HSP response. These studies also raise thepossibility of a functional role for HSPs in the allogeneic immune response.

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Documento generato il 12/07/20 alle ore 06:36:14