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Titolo:
DRUG-INTERACTIONS AND THE CYTOCHROME-P-450 ENZYMES
Autore:
CARLSTON JA;
Indirizzi:
ALLERGY & ASTHMA SPECIALISTS LTD,1704 SIR WILLIAM OSLER DR VIRGINIA BEACH VA 23454
Titolo Testata:
Pediatric asthma, allergy & immunology
fascicolo: 3, volume: 9, anno: 1995,
pagine: 123 - 132
SICI:
0883-1874(1995)9:3<123:DATCE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROMYCIN BREATH TEST; HUMAN-LIVER; ALFENTANIL METABOLISM; IDENTIFICATION; EXPLANATION; EXPRESSION; CLEARANCE; SEQUENCE; LOCUS; P450;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Carlston, "DRUG-INTERACTIONS AND THE CYTOCHROME-P-450 ENZYMES", Pediatric asthma, allergy & immunology, 9(3), 1995, pp. 123-132

Abstract

The catabolism of drugs by the cytochrome P-450 enzymes is germane tothe understanding of drug interactions. This is true for the allergist and all prescribing physicians. These data go beyond the well known toxicity of theophylline, as well as terfenadine and astemizole. Genetically, these naturally occurring enzymes can vary from 10- to 30-fold. The addition of a strong inhibitor or inducer of these enzymes multiplies the toxicity or deletes the effective action of many drugs. It is also important to know the effects of these inhibitors or inducers on substrates other than theophylline and terfenadine. Some substrates are naturally occurring hormones, chemicals in our environment, and carcinogens, including cigarette smoke. Some of these same agents may also act as inhibitors or inducers for other enzymes. This paper explains the genetic derivation of these various enzymes, and how they work. The nomenclature for these enzymes, both old and new, is included. Methods of determining titers of each enzyme in different patients are also described. In the future, the knowledge of a patient's genetically derived enzyme profile will allow us to tailor drug doses precisely, instead of the current standard of ''start low, go slow. '' For the present, knowledge of the many drug interactions cited is essential for any practicing physician, primarily to avoid problems, but also to treatproblems by using inducers (and occasionally inhibitors) as antidotes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 08:13:16