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Titolo:
DETERMINATION OF N-NITROSODIETHANOLAMINE AS NITRITE IN ETHANOLAMINE DERIVATIVE RAW-MATERIALS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITHFLUORESCENCE DETECTION AFTER ALKALINE DENITROSATION
Autore:
DIALLO S; ZHOU JY; DAUPHIN C; PROGNON P; HAMON M;
Indirizzi:
FAC PHARM CHATENAY MALABRY,LAB CHIM ANALYT 2,5 RUE JB CLEMENT F-92290CHATENAY MALABRY FRANCE FAC PHARM CHATENAY MALABRY,LAB CHIM ANALYT 2 F-92290 CHATENAY MALABRYFRANCE
Titolo Testata:
Journal of chromatography
fascicolo: 1, volume: 721, anno: 1996,
pagine: 75 - 81
Fonte:
ISI
Lingua:
ENG
Soggetto:
COSMETIC PRODUCTS; NITROSO COMPOUNDS; SHAMPOOS;
Keywords:
DERIVATIZATION, LC; N-NITROSODIETHANOLAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Diallo et al., "DETERMINATION OF N-NITROSODIETHANOLAMINE AS NITRITE IN ETHANOLAMINE DERIVATIVE RAW-MATERIALS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITHFLUORESCENCE DETECTION AFTER ALKALINE DENITROSATION", Journal of chromatography, 721(1), 1996, pp. 75-81

Abstract

A precise and sensitive method is described for the determination of N-nitrosodiethanolamine (NDELA) at the 1 mu g l(-1) level. NDELA was found to be extracted from aqueous solution by ethyl acetate at pH 1.0. The technique is based on the alkaline denitrosation of NDELA and reaction of the nitrite liberated with Coumarin 120 (4-methyl-7-aminocoumarin) in sulphuric acid medium to give the corresponding 7-diazo compound. After hydrolysis at 100 degrees C, the corresponding 7-hydroxycoumarin (4-methylumbelliferone) is detected fluorimetrically at 380 nm after excitation at 325 nn. HPLC is essential to separate excess Coumarin 120 from 4-methylumbelliferone. Linearity was obtained from 1 to 30mu g l(-1) (r = 0.997). The limit of detection was 0.8 mu g l(-1) fora signal-to-noise ratio of 3. The repeatability expressed as R.S.D. was 6.8% at 1 mu g l(-1) and 5.5% at 30 mu g l(-1). The reproducibility, established by two operators on three consecutive days at 5 mu g l(-1) (n = 6), was 9.2% (R.S.D.). Under the conditions adopted, detectionof trace levels of NDELA in ethanolamine derivatives is possible.

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Documento generato il 07/04/20 alle ore 22:47:51