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Titolo:
IGG SUBCLASS DEFICIENCIES ASSOCIATED WITH BRONCHIECTASIS
Autore:
DEGRACIA J; RODRIGO MJ; MORELL F; VENDRELL M; MIRAVITLLES M; CRUZ MJ; CODINA R; BOFILL JM;
Indirizzi:
PADRE CLARET 282 B,3-2 E-08026 BARCELONA SPAIN HOSP GEN UNIV VALL HEBRON,SERV BIOQUIM,UNITAT IMMUNOL,SERV PNEUMOL BARCELONA SPAIN
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 2, volume: 153, anno: 1996,
pagine: 650 - 655
SICI:
1073-449X(1996)153:2<650:ISDAWB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPSULAR POLYSACCHARIDE ANTIGEN; CHRONIC BRONCHIAL SUPPURATION; IMMUNOLOGICAL ABNORMALITIES; RECURRENT INFECTIONS; RESPIRATORY-FUNCTION; ANTIBODY-RESPONSE; IMMUNODEFICIENCY; GLOBULIN; POPULATION; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J. Degracia et al., "IGG SUBCLASS DEFICIENCIES ASSOCIATED WITH BRONCHIECTASIS", American journal of respiratory and critical care medicine, 153(2), 1996, pp. 650-655

Abstract

Only a small number of patients with IgG subclass deficiencies (IgGSD) have been observed to have bronchiectasis. Moreover, in the series of patients with bronchiectasis, IgGSD have not been found at any frequency, and the etiology of bronchiectasis remains unclear in 29 to 49% of cases. Serum concentrations of total IgG, IgA, and IgG subclasses as well as pulmonary function were measured in 65 patients (aged: 10 to74 yr) with bronchiectasis of unknown etiology. An ELISA test was performed to quantify subclasses 1 through 4 using subclass-specific antihuman monoclonal antibodies. IgG subclass estimation in a healthy population with age-stratified normal ranges was derived from 100 adults, 37 children aged between 10 and 12 yr, and 27 adolescents aged between13 and 16 yr. Serum concentrations of specific IgG antibodies to Haemophilus influenzae type b capsular polysaccharide (Hib-PRP) were also assayed by an ELISA test in 19 of the patients (10 with IgGSD and ninewith non-IgGSD) and in 58 healthy individuals before and 3 wk after immunization with Hib-PRP conjugated to meningococcal outer membrane protein complex (OMPC). Thirty-one patients (48%) had low serum concentrations of one or more IgG subclasses (19 IgG2 deficiencies, 2 IgG3 deficiencies, 3 IgG4 deficiencies, and 7 combined subclass deficiencies). All patients showed increased levels of total IgG, IgG1, and IgA, butthis rise was significantly higher in patients without IgGSD. Patients with IgGSD showed impaired antibody response to Hib-PRP compared with patients with non-IgGSD and the control group. IgGSD, particularly IgG2 deficiency, are not an unusual cause of bronchiectasis. Therefore,serum levels of IgG subclasses must be assayed whenever other causes of bronchiectasis have been ruled out.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 07:34:07