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Titolo:
RECOMBINATION ASSOCIATED WITH REPLICATION OF MALARIAL MITOCHONDRIAL-DNA
Autore:
PREISER PR; WILSON RJM; MOORE PW; MCCREADY S; HAJIBAGHERI MAN; BLIGHT KJ; STRATH M; WILLIAMSON DH;
Indirizzi:
NATL INST MED RES,DIV PARASITOL,RIDGEWAY,MILL HILL LONDON NW7 1AA ENGLAND NATL INST MED RES,DIV PARASITOL LONDON NW7 1AA ENGLAND UNIV OXFORD,DEPT BIOCHEM OXFORD OX1 3QU ENGLAND IMPERIAL CANC RES FUND LONDON WC2A 3PX ENGLAND
Titolo Testata:
EMBO journal
fascicolo: 3, volume: 15, anno: 1996,
pagine: 684 - 693
SICI:
0261-4189(1996)15:3<684:RAWROM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARASITE PLASMODIUM-FALCIPARUM; GALLINACEUM; MICROSCOPY; SEQUENCES; GENOMES; ELEMENT; CULTURE; GENES;
Keywords:
MTDNA; PLASMODIUM FALCIPARUM; RECOMBINATION; REPLICATION; ROLLING CIRCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
P.R. Preiser et al., "RECOMBINATION ASSOCIATED WITH REPLICATION OF MALARIAL MITOCHONDRIAL-DNA", EMBO journal, 15(3), 1996, pp. 684-693

Abstract

Mitochondrial DNA of the malarial parasite Plasmodium falciparum comprises similar to 20 copies per cell of a 6 kb genome, arranged mainly as polydisperse linear concatemers. In synchronous blood cultures, initiation of mtDNA replication coincides with the start of the 4-5 doublings in nuclear DNA that mark the reproductive phase of the erythrocytic cycle. We show that mtDNA replication coincides with a recombination process reminiscent of the replication mechanism used by certain bacteriophages and plasmids. The few circular forms of mtDNA which are also present do not replicate by a theta mechanism, but are themselves the product of recombination, and we propose they undergo rolling circle activity to generate the linear concatemers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:59:57