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Titolo:
ALVEOLAR SURFACTANT AGGREGATE CONVERSION IN VENTILATED NORMAL AND INJURED RABBITS
Autore:
VELDHUIZEN RAW; MARCOU J; YAO LJ; MCCAIG L; ITO Y; LEWIS JF;
Indirizzi:
ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT MED,RM H417,268 GROSVENOR STLONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,DEPT PHYSIOL LONDON ON N6A 5A5 CANADA UNIV WESTERN ONTARIO,DEPT MED LONDON ON N6A 5A5 CANADA
Titolo Testata:
American journal of physiology. Lung cellular and molecular physiology
fascicolo: 1, volume: 14, anno: 1996,
pagine: 152 - 158
SICI:
1040-0605(1996)14:1<152:ASACIV>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY SURFACTANT; EXTRACELLULAR METABOLISM; LUNG; SUBFRACTIONS; SUBTYPES; PHOSPHATIDYLCHOLINE; INVITRO; MICE;
Keywords:
VENTILATION; LUNG INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
R.A.W. Veldhuizen et al., "ALVEOLAR SURFACTANT AGGREGATE CONVERSION IN VENTILATED NORMAL AND INJURED RABBITS", American journal of physiology. Lung cellular and molecular physiology, 14(1), 1996, pp. 152-158

Abstract

Alveolar surfactant can be separated into two subtypes; large aggregates and small aggregates. Large aggregates represent the surface active form of surfactant and are the metabolic precursors of small aggregates. Previous studies examined the mechanism by which large aggregatesare converted into small aggregates in vitro. We used intratracheal injection of radiolabeled large aggregates in rabbits to probe the aggregate conversion in vivo. After this injection, animals were mechanically ventilated for 60 min. After the animals were billed, the lungs were lavaged, and the percentage of radiolabel present in the small aggregate fraction was determined. Our results showed that ventilation resulted in aggregate conversion and that increases in tidal volume, but not in respiratory rate, correlated with increased conversion. Aggregate conversion in rabbits with acute lung injury correlated significantly with severity of injury. We conclude that a change in surface area (i.e., respiration) is necessary for aggregate conversion in vivo and that the ventilation strategy can affect this conversion. Furthermore,increased aggregate conversion in injured lungs might contribute to increased small-to-large aggregate ratios in these lungs compared with normal lungs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:32:53