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Titolo:
SELECTIVE CYTOTOXICITY OF RICIN A CHAIN IMMUNOTOXINS TOWARDS MURINE CYTOMEGALOVIRUS-INFECTED CELLS
Autore:
BARNETT BB; SMEE DF; MALEK SM; SIDWELL RW;
Indirizzi:
UTAH STATE UNIV,DEPT BIOL LOGAN UT 84322 UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI LOGAN UT 84322
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 2, volume: 40, anno: 1996,
pagine: 470 - 472
SICI:
0066-4804(1996)40:2<470:SCORAC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED IMMUNODEFICIENCY SYNDROME; BONE-MARROW-TRANSPLANT; A-CHAIN; VIRUS RETINITIS; T-CELLS; PHASE-I; INVITRO; GANCICLOVIR; ANTIBODIES; FOSCARNET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
B.B. Barnett et al., "SELECTIVE CYTOTOXICITY OF RICIN A CHAIN IMMUNOTOXINS TOWARDS MURINE CYTOMEGALOVIRUS-INFECTED CELLS", Antimicrobial agents and chemotherapy, 40(2), 1996, pp. 470-472

Abstract

Immunotoxins were constructed by linking immunoglobulins specific formurine cytomegalovirus (MCMV) to deglycosylated ricin A chain. Toxicities toward MCMV-infected and uninfected cells were determined by measuring the inhibition of protein synthesis following a 48-h exposure toimmunotoxins commencing 24 h after infection. The 50% inhibitory concentrations ranged from 0.4 to 4 mu g/ml for infected cells and from 22to 120 mu g/ml for uninfected cells. Selectivity indices ranged from 30 to 157. Control immunotoxins, which were constructed identically except that the immunoglobulin moiety had no specificity toward MCMV antigens, had 50% inhibitory concentrations of 50 and 100 mu g/ml toward infected and uninfected cells, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:34:36