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Titolo:
CATHEPSIN-G IN GINGIVAL TISSUE AND CREVICULAR FLUID IN ADULT PERIODONTITIS
Autore:
TERVAHARTIALA T; KONTTINEN YT; INGMAN T; HAYRINENIMMONEN R; DING Y; SORSA T;
Indirizzi:
UNIV HELSINKI,DEPT PERIODONTOL,INST DENT,RES LAB,POB 41,MANNERHEIMINTIE 172 SF-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT ANAT SF-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT MED CHEM SF-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT ORAL & MAXILLOFACIAL SURG SF-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT ORTHODONT & PERIDONT SF-00014 HELSINKI FINLAND UNIV HELSINKI,CENT HOSP,DEPT MED 4 SF-00014 HELSINKI FINLAND
Titolo Testata:
Journal of clinical periodontology
fascicolo: 2, volume: 23, anno: 1996,
pagine: 68 - 75
SICI:
0303-6979(1996)23:2<68:CIGTAC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN NEUTROPHIL COLLAGENASE; LATENT HUMAN NEUTROPHIL; INTERSTITIAL COLLAGENASES; POLYMORPHONUCLEAR LEUKOCYTES; JUVENILE PERIODONTITIS; SERINE PROTEINASES; HUMAN-MONOCYTES; ELASTASE; ACTIVATION; PROTEASES;
Keywords:
CATHEPSIN G; ALPHA(1)-ANTICHYMOTRYPSIN; PERIODONTITIS; INFLAMMATION; GINGIVAL CREVICULAR FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
T. Tervahartiala et al., "CATHEPSIN-G IN GINGIVAL TISSUE AND CREVICULAR FLUID IN ADULT PERIODONTITIS", Journal of clinical periodontology, 23(2), 1996, pp. 68-75

Abstract

The presence, localization and activities of cathepsin G in gingival tissue specimens and crevicular fluid (GCF) from 9 adult periodontitispatients and 6 controls with clinically healthy periodontium were studied by use of avidin-biotin-peroxidase complex method, Western and dot blotting, and spectrophotometric activity assay. In contrast to healthy gingival tissue specimens, gingival tissue specimens collected from adult periodontitis patients contained inflammatory cells in lamina propria, beneath the oral sulcular epithelium. 10-50% of which were cathepsin G positive polymorphonuclear neutrophilic leukocytes (PMNs) and monocyte/macrophage-like cells. Cathepsin G activities were increased in adult periodontitis GCF when compared to periodontally healthy controls GCF (p<0.05). In adult periodontitis GCE, Western blotting disclosed free cathepsin G but also clear complexes of cathepsin G with its predominant endogenous inhibitor alpha(1)-antichymotrypsin (alpha(1)-ACT), The present results demonstrate that part of the cathepsin G, despite the presence of increased concentrations of alpha(1)-ACT, was in an uncomplexed, free and functionally active form. Our results suggest that GCF cathepsin G reflects the disease process in adjacent inflamed gingiva and also increased host response to microbiota and/or dental plaque in the periodontitis lesions. Cathepsin G may contribute to periodontal tissue destruction directly and indirectly, via proteolytic activation of latent neutrophil procollagenase (promatrix metalloproteinase-8 [proMMP-8]).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:34:51