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Titolo:
EFFECTS OF ADRENALECTOMY OR RU-486 ON RAT MUSCLE-FIBERS DURING HINDLIMB SUSPENSION
Autore:
ABOUDRAR S; SEMPORE B; KOUBI H; DECHAUD H; DESPLANCHES D;
Indirizzi:
FAC MED LYON GRANGE BLANCHE,PHYSIOL LAB,CNRS,URA 1341 F-69373 LYON 08FRANCE FAC MED LYON GRANGE BLANCHE,PHYSIOL LAB,CNRS,URA 1341 F-69373 LYON 08FRANCE
Titolo Testata:
Journal of applied physiology
fascicolo: 6, volume: 75, anno: 1993,
pagine: 2767 - 2773
SICI:
8750-7587(1993)75:6<2767:EOAORO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; SOLEUS MUSCLE; GLUCOCORTICOID ANTAGONIST; PROTEIN BREAKDOWN; ANABOLIC-STEROIDS; MYOSIN HEAVY; ATROPHY; SPACEFLIGHT; RESPONSES; EXERCISE;
Keywords:
HISTOCHEMISTRY; GLUCOCORTICOIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S. Aboudrar et al., "EFFECTS OF ADRENALECTOMY OR RU-486 ON RAT MUSCLE-FIBERS DURING HINDLIMB SUSPENSION", Journal of applied physiology, 75(6), 1993, pp. 2767-2773

Abstract

The purpose of this study was to investigate the effects of a glucocorticoid antagonist, RU-486, and of adrenalectomy (ADX) on rat skeletalmuscle structural properties after 3, 7, and 14 days of hindlimb suspension (H). After H, a significant loss in muscle weight was observed as early as 3 days in soleus (SOL; -10%) and adductor longus (AL; -14%) muscles. In SOL, after only 7 days, a reduction (-14%) in type I fiber percent distribution occurred, accompanied by an increase (+129%) in intermediate type I fibers. Fiber type changes increased depending on the duration of H. In AL muscle, no change occurred after H in the fiber type composition despite a similar degree of muscle atrophy. Treatment with RU-486 or ADX significantly reduced the loss of SOL weight observed after 14 days (-42 and -44%, respectively, vs. -50% for H rats), delayed the SOL atrophy (from 3 to 7 days), and normalized the shift in fiber type distribution induced by H. In SOL, administration of RU-486 (but not ADX) partly prevented the reduction in size induced byH of all the fibers. In AL, neither treatment affected the extent of muscle atrophy, even though the reduction in type IIa fiber size was prevented by RU-486 but not by ADX after 14 days of suspension. ADX or RU-486 administration did not prevent the extensor digitorum longus weight loss observed after 14 days of suspension but allowed a recovery of its normal fiber type composition. Our data suggest a minor role ofglucocorticoid hormones in regulating SOL weight and suggest a major role in regulating SOL fiber type composition during H.

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Documento generato il 30/11/20 alle ore 18:10:20