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Titolo:
TRANSFER OF BETA-AMYLOID PRECURSOR PROTEIN GENE USING ADENOVIRUS VECTOR CAUSES MITOCHONDRIAL ABNORMALITIES IN CULTURED NORMAL HUMAN MUSCLE
Autore:
ASKANAS V; MCFERRIN J; BAQUE S; ALVAREZ RB; SARKOZI E; ENGEL WK;
Indirizzi:
UNIV SO CALIF,SCH MED,HOSP GOOD SAMARITAN,DEPT NEUROL,NEUROMUSCULAR CTR,637 S LUCAS AVE LOS ANGELES CA 90017
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 3, volume: 93, anno: 1996,
pagine: 1314 - 1319
SICI:
0027-8424(1996)93:3<1314:TOBPPG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCLUSION-BODY MYOSITIS; ALZHEIMERS-DISEASE; MESSENGER-RNA; UBIQUITIN; BIOPSIES; FIBERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
V. Askanas et al., "TRANSFER OF BETA-AMYLOID PRECURSOR PROTEIN GENE USING ADENOVIRUS VECTOR CAUSES MITOCHONDRIAL ABNORMALITIES IN CULTURED NORMAL HUMAN MUSCLE", Proceedings of the National Academy of Sciences of the United Statesof America, 93(3), 1996, pp. 1314-1319

Abstract

As in Alzheimer-disease (AD) brain, vacuolated muscle fibers of inclusion-body myositis (IBIM) contain abnormally accumulated beta-amyloid precursor protein (beta APP), including its beta-amyloid protein epitope, and increased beta APP-751 mRNA, Other similarities between IBM muscle and AD brain phenotypes include paired helical filaments, hyperphosphorylated tau protein, apolipoprotein E, and mitochondrial abnormalities, including decreased cytochrome-c oxidase (COX) activity, The pathogenesis of these abnormalities in IBIM muscle and AD brain is not known, We now report that direct transfer of the beta APP gene, using adenovirus vector, into cultured normal human muscle fibers causes structural abnormalities of mitochondria and decreased COX activity, In this adenovirus-mediated beta APP gene transfer, we demonstrated that beta APP overproduction can induce mitochondrial abnormalities, The datasuggest that excessive beta APP may be responsible for mitochondrial and COX abnormalities in IBM muscle and perhaps AD brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 04:01:50