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Titolo:
THICKENING OF THE CAROTID WALL - A MARKER FOR ATHEROSCLEROSIS IN THE ELDERLY
Autore:
OLEARY DH; POLAK JF; KRONMAL RA; SAVAGE PJ; BORHANI NO; KITTNER SJ; TRACY R; GARDIN JM; PRICE TR; FURBERG CD;
Indirizzi:
CHS COORDINATING CTR,CENTURY SQ,1501 4TH AVE,SUITE 2025 SEATTLE WA 98101 TUFTS UNIV,NEW ENGLAND MED CTR,DEPT RADIOL BOSTON MA 02111 BRIGHAM & WOMENS HOSP,DEPT RADIOL BOSTON MA 02115 WASHINGTON UNIV,DEPT BIOSTAT SEATTLE WA 00000 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV PITTSBURGH,DEPT NEUROSURG PITTSBURGH PA 00000 UNIV MARYLAND,DEPT NEUROL BALTIMORE MD 21201 UNIV VERMONT,DEPT PATHOL COLCHESTER ESSEX ENGLAND UNIV CALIF IRVINE IRVINE CA 92717 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103
Titolo Testata:
Stroke
fascicolo: 2, volume: 27, anno: 1996,
pagine: 224 - 231
SICI:
0039-2499(1996)27:2<224:TOTCW->2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-MODE ULTRASOUND; INTIMA-MEDIA THICKNESS; DENSITY-LIPOPROTEIN CHOLESTEROL; COLESTIPOL-NIACIN THERAPY; CARDIOVASCULAR HEALTH; PATHOLOGIC FINDINGS; CEREBRAL-ISCHEMIA; ARTERY DISEASE; PULSATILE FLOW; SHEAR-STRESS;
Keywords:
CAROTID ARTERIES; DIAGNOSTIC IMAGING; ELDERLY; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
D.H. Oleary et al., "THICKENING OF THE CAROTID WALL - A MARKER FOR ATHEROSCLEROSIS IN THE ELDERLY", Stroke, 27(2), 1996, pp. 224-231

Abstract

Background and Purpose We investigated the relationships between prevalent coronary heart disease (CHD), clinically manifest atherosclerotic disease (ASD), and major established risk factors for atherosclerosis and intima-media thickness (IMT) in the common carotid arteries (CCA) and internal carotid arteries (ICA) separately and in combination inolder adults. We wished to determine whether a noninvasive measurement can serve as an indicator of clinically manifest atherosclerotic disease and to determine which of the two variables, CCA IMT or ICA IMT, is a better correlate. Methods IMT of the CCA and ICA was measured with duplex ultrasound in 5117 of 5201 individuals enrolled in the Cardiovascular Health Study, a study of the risk factors and the natural history of cardiovascular disease in adults aged 65 years or more. Histories of CHD, peripheral arterial disease, and cerebrovascular disease were obtained during baseline examination. Risk factors included cholesterol levels. cigarette smoking, elevated blood pressure, diabetes? age, and sex. Relationships between risk factors and IMT were studied bymultiple regression analysis and canonical variate analysis. Prediction of prevalent CHD and ASD by IMT measurements in CCAs and ICAs were made by logistic regression, adjusting for age and sex. Results IMT measurements of the CCAs and ICAs were greater in persons with CHD and ASD than those without, even after controlling for sex (P<.001). IMT measurements in the ICA were greater than those in the CCA. Risk factorsfor ASD accounted for 17% and 18% of the variability in IMT in the CCA and ICA, respectively. These same risk factors accounted for 25% of the variability of a composite measurement consisting of the sum of the ICA IMT and CCA IMT. The ability to predict CHD and ASD was greater for ICA IMT (odds ratio [confidence interval]: 1.36 [1.31 to 1.41] and1.35 [1.25 to 1.44], respectively) than for CCA IMT (1.09 [1.05 to 1.13] and 1.17 [1.09 to 1.25]). Conclusions Whereas CCA IMT is associated with major risk factors for atherosclerosis and existing CI-ID and ASD in older adults, this association is not as strong as that for ICA IMT. The combination of these measures relates more strongly to existing CHD and ASD and cerebrovascular disease risk factors than either taken alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 16:44:06