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Titolo:
HEMOCHROME PARAMETERS DURING THE FIRST 2 YEARS OF LIFE IN CHILDREN WITH PERINATAL HIV-1 INFECTION
Autore:
GALLI L; DEMARTINO M; ROSSI ME; PANZA B; FARINA S; VIERUCCI A;
Indirizzi:
UNIV FLORENCE,DEPT PEDIAT FLORENCE ITALY
Titolo Testata:
Pediatric AIDS and HIV infection
fascicolo: 6, volume: 6, anno: 1995,
pagine: 340 - 345
SICI:
1045-5418(1995)6:6<340:HPDTF2>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PROGENITOR CELLS; BONE-MARROW; INFANTS; GROWTH; TYPE-1; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
L. Galli et al., "HEMOCHROME PARAMETERS DURING THE FIRST 2 YEARS OF LIFE IN CHILDREN WITH PERINATAL HIV-1 INFECTION", Pediatric AIDS and HIV infection, 6(6), 1995, pp. 340-345

Abstract

Monthly hemochrome parameters were obtained during the first 2 years of age in 22 children with perinatal human immunodeficiency virus type-1 (HIV-1) infection and in 58 exposed seroreverted children. Timing and predictive value of hemochrome modifications were investigated. Exclusion criteria were hemoglobinopathies and zidovudine (AZT) treatmentin pregnancy. When AZT treatment was undertaken children were eliminated from the study. From the second month of life red blood cell (RBC)counts, hemoglobin (Hb) concentrations, and hematocrit values were significantly lower in infected than in uninfected children. RBC counts progressively diverged in infected and uninfected children, and mean values in the former group never reached 4.10(12)/L. No difference was observed in Hb content ratios and RBC size parameters. At 2 months RBCcounts, Hb concentrations, and hematocrit values below reference values were associated with a 15.8 (95% confidence limits [CL]: 5.5-48.8) relative risk of being infected. In infected infants aged 5 months a decrease in these parameters was associated with an 11.2 (95% CL: 1.6-77.8) relative risk of developing eventual severe clinical outcome. LowRBC counts, Hb concentrations, and hematocrit values may be included among predictive criteria in infants of HIV-1-infected mothers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:23:07