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Titolo:
ALZHEIMER-ASSOCIATED PRESENILIN-1 AND PRESENILIN-2 - NEURONAL EXPRESSION IN BRAIN AND LOCALIZATION TO INTRACELLULAR MEMBRANES IN MAMMALIAN-CELLS
Autore:
KOVACS DM; FAUSETT HJ; PAGE KJ; KIM TW; MOIR RD; MERRIAM DE; HOLLISTER RD; HALLMARK OG; MANCINI R; FELSENSTEIN KM; HYMAN BT; TANZI RE; WASCO W;
Indirizzi:
HARVARD UNIV,MASSACHUSETTS GEN HOSP EAST,SCH MED,GENET & AGING UNIT,149 13TH ST BOSTON MA 02129 HARVARD UNIV,MASSACHUSETTS GEN HOSP EAST,SCH MED,GENET & AGING UNIT BOSTON MA 02129 HARVARD UNIV,MASSACHUSETTS GEN HOSP EAST,SCH MED,DEPT NEUROL BOSTON MA 02129 BRISTOL MYERS SQUIBB CO,DEPT 405 WALLINGFORD CT 06492
Titolo Testata:
Nature medicine
fascicolo: 2, volume: 2, anno: 1996,
pagine: 224 - 229
SICI:
1078-8956(1996)2:2<224:APAP-N>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-PROTEIN PRECURSOR; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Kovacs et al., "ALZHEIMER-ASSOCIATED PRESENILIN-1 AND PRESENILIN-2 - NEURONAL EXPRESSION IN BRAIN AND LOCALIZATION TO INTRACELLULAR MEMBRANES IN MAMMALIAN-CELLS", Nature medicine, 2(2), 1996, pp. 224-229

Abstract

Mutations in two recently identified genes appear to cause the majority of early-onset familial Alzheimer's disease (FAD). These two novel genes, presenilin 1 (PS1) and presenilin 2 (PS2) are members of an evolutionarily conserved gene family. The normal biological role(s) of the presenilins and the mechanism(s) by which the FAD-associated mutations exert their effect remain unknown. Employing in situ hybridization,we demonstrate that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicate that PS1 and PS2 are similar in size and localized to similarintracellular compartments (endoplasmic reticulum and Golgi complex). FAD-associated mutations in PS1 and PS2 do not significantly modify either their migration patterns on SDS-polyacrylamide gel electrophoresis or their overall subcellular localization, although subtle differences in perinuclear staining were noted for mutant PS1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:21:32