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Titolo:
ANTIBODY AND COMPLEMENT REDUCE RENAL HEMODYNAMIC FUNCTION IN ISOLATED-PERFUSED RAT-KIDNEY
Autore:
JOCKS T; ZAHNER G; HELMCHEN U; KNEISSLER U; STAHL RAK;
Indirizzi:
UNIV HAMBURG,HOSP EPPENDORF,MED KLIN,ABT NEPHROL & OSTEOL,MARTINISTR 52 D-20246 HAMBURG GERMANY UNIV HAMBURG,DEPT MED,DIV NEPHROL D-20246 HAMBURG GERMANY UNIV HAMBURG,DEPT PATHOL D-20246 HAMBURG GERMANY
Titolo Testata:
American journal of physiology. Renal, fluid and electrolyte physiology
fascicolo: 1, volume: 39, anno: 1996,
pagine: 179 - 185
SICI:
0363-6127(1996)39:1<179:AACRRH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR PROSTAGLANDIN FORMATION; MESANGIAL CELL INJURY; MEMBRANOUS NEPHROPATHY; THROMBOXANE SYNTHESIS; GLOMERULONEPHRITIS; SERUM; INHIBITION; FEEDBACK;
Keywords:
ANTI-THYMOCYTE ANTIBODY; DALTROBAN; RENAL VASCULAR RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
T. Jocks et al., "ANTIBODY AND COMPLEMENT REDUCE RENAL HEMODYNAMIC FUNCTION IN ISOLATED-PERFUSED RAT-KIDNEY", American journal of physiology. Renal, fluid and electrolyte physiology, 39(1), 1996, pp. 179-185

Abstract

To evaluate the effect of antibody and complement on renal hemodynamic changes, glomerular injury was induced in isolated perfused kidneys by an anti-thymocyte antibody (ATS) and rat serum (RS). Glomerular filtration rate (GFR), renal vascular resistance (RVR), and renal perfusate flow (RPF) were assessed over an 80-min period. The possible role of thromboxane (Tx) was tested by the application of the Tx synthesis inhibitor UK-38485 and the Tx receptor blocker daltroban. Perfusion of kidneys with ATS and RS significantly reduced GFR at 10 min (control, 501 +/- 111; ATS + RS, 138 +/- 86 ml . g kidney(-1). min(-1), significance of F = 0.000) after RS. Similarly, RPF (ml . g kidney(-1). min(-1)) fell from 19.2 +/- 1.8 to 6.1 +/- 2.0 (significance of F = 0.000), whereas RVR (mmHg . ml(-1). g . min) increased threefold from 5.2 +/- 0.4 to 17.9 +/- 5.0 at 10 min. These changes were ameliorated by the pretreatment of the rats with daltroban and UK-38485. Addition of erythrocytes to the perfusate increased RVR and GFR, whereas RPF decreased compared with cell-free perfused kidneys. ATS and RS in this preparation also decrease GFR and RPF. The hemodynamic alterations appeared without changes in filtration fraction. Compared with untreated, perfusedcontrol kidneys, glomerular Tx formation was significantly increased in ATS and RS perfused kidneys. These data demonstrate that antibody and RS induce impairment of renal hemodynamics, which are mediated by increased Tx formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:20:05