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Titolo:
AUTOMATIC ATLAS-BASED VOLUME ESTIMATION OF HUMAN BRAIN-REGIONS FROM MR-IMAGES
Autore:
ANDREASEN NC; RAJARETHINAM R; CIZADLO T; ARNDT S; SWAYZE VW; FLASHMAN LA; OLEARY DS; EHRHARDT JC; YUH WTC;
Indirizzi:
UNIV IOWA HOSP & CLIN,COLL MED,MENTAL HLTH CLIN RES CTR,200 HAWKINS DR,RM 2911 JPP IOWA CITY IA 52242 UNIV IOWA HOSP & CLIN,COLL MED,DEPT PSYCHIAT IOWA CITY IA 52242 UNIV IOWA HOSP & CLIN,COLL MED,DEPT RADIOL IOWA CITY IA 52242
Titolo Testata:
Journal of computer assisted tomography
fascicolo: 1, volume: 20, anno: 1996,
pagine: 98 - 106
SICI:
0363-8715(1996)20:1<98:AAVEOH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRUCTURAL ABNORMALITIES; TEMPORAL LOBES; SCHIZOPHRENIA; ASYMMETRIES; CORTEX; INTELLIGENCE; TOMOGRAPHY;
Keywords:
MAGNETIC RESONANCE IMAGING, PHYSICS AND INSTRUMENTATION; MAGNETIC RESONANCE IMAGING, TECHNIQUES; BRAIN; ATLAS AND ATLASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
N.C. Andreasen et al., "AUTOMATIC ATLAS-BASED VOLUME ESTIMATION OF HUMAN BRAIN-REGIONS FROM MR-IMAGES", Journal of computer assisted tomography, 20(1), 1996, pp. 98-106

Abstract

Objective: MRI offers many opportunities for noninvasive in vivo measurement of structure-function relationships in the human brain. Although automated methods are now available for whole-brain measurements, an efficient and valid automatic method for volume estimation of subregions such as the frontal or temporal lobes is still needed. Materials and Methods: We adapted the Talairach atlas to the study of brain subregions. We supplemented the atlas with additional boxes to include thecerebellum. We assigned all the boxes to 1 of 12 regions of interest (ROIs) (frontal, parietal, temporal, and occipital lobes, cerebellum, and subcortical regions on right and left sides of the brain). Using T1-weighted MR scans collected with an SPGR sequence (slice thickness =1.5 mm), we manually traced these ROIs and produced volume estimates. We then transformed the scans into Talairach space and compared the volumes produced by the two methods (''traced'' versus ''automatic''). The traced measurements were considered to be the ''gold standard'' against which the automatic measurements were compared. Results: The automatic method was found to produce measurements that were nearly identical to the traced method. We compared absolute measurements of volumeproduced by the two methods, as well as the sensitivity and specificity of the automatic method. We also compared the measurements of cerebral blood flow obtained through [O-15]H2O PET studies in a sample of nine subjects. Absolute measurements of volume produced by the two methods were very similar, and the sensitivity and specificity of the automatic method were found to be high for all regions. The flow values were also found to be very similar by both methods. Conclusion: The automatic atlas-based method for measuring the volume of brain subregions produces results that are similar to manual techniques. The method is rapid, efficient, unbiased, and not subject to the problems of rater drift or potentially poor interrater reliability that plague manual methods. Consequently, this method may be very useful for the study of structure-function relationships in the human brain.

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Documento generato il 07/07/20 alle ore 12:23:35