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Titolo:
IDENTIFICATION OF A COMMITTED PRECURSOR FOR THE MAST-CELL LINEAGE
Autore:
RODEWALD HR; DESSING M; DVORAK AM; GALLI SJ;
Indirizzi:
BASEL INST IMMUNOL,GRENZACHERSTR 487 CH-4005 BASEL SWITZERLAND HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DEPT PATHOL BOSTON MA 02215
Titolo Testata:
Science
fascicolo: 5250, volume: 271, anno: 1996,
pagine: 818 - 822
SICI:
0036-8075(1996)271:5250<818:IOACPF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW; PERIPHERAL-BLOOD; MICE; HYPERSENSITIVITY; INTERLEUKIN-4; ESTABLISHMENT; MATURATION; EXPRESSION; RECEPTORS; BASOPHILS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Rodewald et al., "IDENTIFICATION OF A COMMITTED PRECURSOR FOR THE MAST-CELL LINEAGE", Science, 271(5250), 1996, pp. 818-822

Abstract

Mast cells originate from hematopoietic stem cells, but the mast cell-committed precursor has not been identified. In the study presented here, a cell population in murine fetal blood that fulfills the criteria of progenitor mastocytes was identified. It is defined by the phenotype Thy-1(lo)c-Kit(hi), contains cytoplasmic granules, and expresses RNAs encoding mast cell-associated proteases but lacks expression of the high-affinity immunoglobulin E receptor. Thy-1(lo)c-Kit(hi) cells generated functionally competent mast cells at high frequencies in vitrobut lacked developmental potential for other hematopoietic lineages. When transferred intraperitoneally, this population reconstituted the peritoneal mast cell compartment of genetically mast cell-deficient W/W-v mice to wild-type levels.

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Documento generato il 27/11/20 alle ore 04:22:44