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Titolo:
EFFECT OF BUSPIRONE, A SEROTONERGIC 5-HT1 A AGONIST, IN CEREBELLAR-ATAXIA - A PILOT-STUDY
Autore:
TROUILLAS P; XIE J; GETENET JC; ADELEINE P; NIGHOGHOSSIAN N; HONNORAT T; RICHE G; DEREX L;
Indirizzi:
UNIV LYON 1,CTR RECH ATAXIE,59 BLVD PINEL F-69003 LYON FRANCE UNIV LYON 1,HOP NEUROL,UNITE CEREBROVASC F-69003 LYON FRANCE UNIV LYON 1,FAC ALEXIS CARREL F-69003 LYON FRANCE HOSPICES CIVILS LYON,LAB INFORMAT LYON FRANCE
Titolo Testata:
Revue neurologique
fascicolo: 12, volume: 151, anno: 1995,
pagine: 708 - 713
SICI:
0035-3787(1995)151:12<708:EOBAS5>2.0.ZU;2-4
Fonte:
ISI
Lingua:
FRE
Soggetto:
RAT CEREBELLUM; RECEPTORS; 5-HYDROXYTRYPTOPHAN; PHARMACOLOGY; IMPROVEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
P. Trouillas et al., "EFFECT OF BUSPIRONE, A SEROTONERGIC 5-HT1 A AGONIST, IN CEREBELLAR-ATAXIA - A PILOT-STUDY", Revue neurologique, 151(12), 1995, pp. 708-713

Abstract

We propose a serotonergic hypothesis for cerebellar ataxia. The levorotatory form of 5 hydroxytryptophan has been shown to be partially active in subtypes of cerebellar ataxia, including cerebellar cortical atrophy (CCA). Buspirone, a 5-HT1A agonist usable inhuman medecine, has been studied in a group of 14 patients with cerebellar cortical atrophy. Patients were given Buspirone for 2 months. The evaluation of cerebellar ataxia was made by a semi-quantitative scale, 10 fully quantitative measures and measurements of the sway path and sway area of the center of gravity at posturography. The primary endpoints were the modifications of the ataxia scores. At 2 months, the decrease of the ataxiascores was significant, both in the intention-to-treat (14 cases) andtarget (11 cases) populations. In the target population, secundary endpoints like the time measurements for pronouncing a standard sentence, the time for drawing a ladder and posturographic parameters were significantly improved; the mean global ataxia score was improved by 37.4%. These preliminary date might confirm a link between cerebellar ataxia and the metabolism of serotonin.

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Documento generato il 18/09/20 alle ore 18:59:25