Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EVALUATION OF LATE NEPHROTOXICITY IN LONG-TERM SURVIVORS OF HODGKINS-DISEASE
Autore:
FELS LM; BOKEMEYER C; VANRHEE J; SCHMOLL HJ; STOLTE H;
Indirizzi:
HANNOVER MED SCH,DIV NEPHROL,KONSTANTY GUTSCHOW STR D-30625 HANNOVER GERMANY HANNOVER MED SCH,DEPT HEMATOL & ONCOL D-30625 HANNOVER GERMANY SOC SCI & TECHNOL TRANSFER GWT EV BERLIN GERMANY
Titolo Testata:
Oncology
fascicolo: 1, volume: 53, anno: 1996,
pagine: 73 - 78
SICI:
0030-2414(1996)53:1<73:EOLNIL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
IFOSFAMIDE; MESNA;
Keywords:
HODGKINS DISEASE; TOXICITY, LATE; TOXICITY, RENAL; RADIOTHERAPY; CHEMOTHERAPY; IFOSFAMIDE; METHOTREXATE; CYCLOPHOSPHAMIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Fels et al., "EVALUATION OF LATE NEPHROTOXICITY IN LONG-TERM SURVIVORS OF HODGKINS-DISEASE", Oncology, 53(1), 1996, pp. 73-78

Abstract

Chemotherapy (Ctx) and/or radiotherapy (Rtx) are effective in the treatment of Hodgkin's disease (HD) but potentially involve late toxicities, including nephrotoxic side effects. Therefore a follow-up study has been performed to screen patients for late signs of an impaired tubular or glomerular function and to correlate data of renal function with type of therapy and cumulative doses of cytotoxic agents applied. 81patients in complete remission for at least 2 years and a median follow-up of 96 (39-304) months, and 53 controls were examined. Clinical routine parameters such as creatinine and electrolytes were determined. A differentiation of proteinuria into the albumin, high molecular weight (HMW) and low molecular weight (LMW) fractions made it possible toassess glomerular and tubular function based on the LMW/HMW ratio. The structural protein fibronectin served as an additional, sensitive marker of glomerular integrity. Routine parameters of kidney function did not show any signs of late nephrotoxicity. However, patients treatedfor HD had a higher ratio of LMW/HMW in comparison to the group of healthy volunteers (p < 0.01), indicating subclinical tubular renal damage. When the cutoff for tubular damage was defined as LMW/HMW >1.5, 50% of the patients treated with combined modality, and 42 and 37% of the patients with Ctx or Rtx alone had subclinical tubular alterations, respectively. A tendency towards a higher prevalence of subclinical tubular changes was observed in patients with higher cumulative doses ofmethotrexate or ifosfamide and in patients with combined Ctx and Rtx with radiation fields involving the renal area. Changes in glomerular function were not observed. It is concluded that treatment of HD is not associated with clinically apparent long-term impairment of renal function but can lead to subclinical alterations. Further clinical implications of these subclinical tubular alterations cannot be assessed atpresent. A differentiation of proteinuria does not have to be performed routinely but might be useful in the follow-up of selected patientswith an increased risk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:58:06