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Titolo:
INHIBITORY EFFECT OF PYY ON VAGALLY STIMULATED ACID-SECRETION IS MEDIATED PREDOMINANTLY BY Y-1 RECEPTORS
Autore:
LLOYD KCK; GRANDT D; AURANG K; EYSSELEIN VE; SCHIMICZEK M; REEVE JR;
Indirizzi:
UNIV CALIF LOS ANGELES,VA,CURE,GASTOENTER BIOL CTR,BLDG 115,RM 115 LOS ANGELES CA 90073 W LOS ANGELES VET AFFAIRS MED CTR,DEPT VET AFFAIRS,RES & MED SERV LOSANGELES CA 90073 UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,CTR ULCER RES & EDUC,DIGEST DIS CORE CTR LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,MED CTR LOS ANGELES CA 90073 UNIV KLINIKUM ESSEN,ZENTRUM INNERE MED D-45122 ESSEN GERMANY
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 1, volume: 33, anno: 1996,
pagine: 123 - 127
SICI:
0193-1857(1996)33:1<123:IEOPOV>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE-YY PYY; NEUROPEPTIDE-Y; STRUCTURAL CHARACTERIZATION; SOMATOSTATIN RELEASE; RAT-BRAIN; RABBIT; SOLUBILIZATION; HORMONE; DOG;
Keywords:
PEPTIDE TYROSINE TYROSINE; GASTRIC ACID SECRETION; INSULIN-INDUCED HYPOGLYCEMIA; CEPHALIC PHASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K.C.K. Lloyd et al., "INHIBITORY EFFECT OF PYY ON VAGALLY STIMULATED ACID-SECRETION IS MEDIATED PREDOMINANTLY BY Y-1 RECEPTORS", American journal of physiology: Gastrointestinal and liver physiology, 33(1), 1996, pp. 123-127

Abstract

Two molecular forms of peptide YY (PW), PYY-(1-36) and PYY-(3-36), are abundant in rabbit intestine and blood. We have previously shown that PYY-(1-36) (PW I) activates equipotently Y-1 and Y-2 receptors and PYY-(3-36) (PYY II) is a highly selective agonist for Y-2 receptors. Inthe present study, we examined the effect of exogenous infusion of PYY on vagally stimulated gastric acid secretion in awake rabbits with chronic gastric fistula. To determine the specific PW receptor(s) that mediates this effect, we used a highly selective Y-1 agonist, Pro(34)-PYY, a synthetic PYY, and a Y-2-selective agonist, PYY II. Vagal stimulation of acid secretion was elicited by an intravenous bolus injection of insulin (0.125 U/kg) 30 min after beginning a 180-min intravenousinfusion of either PW I, PYY II, or [Pro(34)]-PYY after a 50 mu g/kg iv bolus of atropine followed immediately by a 500 mu g/kg sc injection. During infusion of 200 pmol . kg(-1). h(-1) PW I, acid output was significantly inhibited to 45 +/- 13% of maximum acid output 60 min after injection of insulin. Similarly, acid output during infusion of 200pmol . kg(-1). h(-1) [Pro(34)]-PYY was significantly inhibited to 52 /- 12% of maximum. In contrast, acid output during infusion of 200 pmol . kg(-1). h(-1) of PW II was not significantly inhibited (101 +/- 18% of maximum). Infusion of double the dose (400 pmol . kg(-1). h(-1))of PYY II resulted in acid inhibition (51 +/- 15% of maximum), whereas infusion of the same dose did not significantly enhance acid inhibition by infusion of either PW I or [Pro(34)]-PYY (28 +/- 11 and 42 +/- 15% of maximum). These results indicate that PYY, acting predominantlyat Y-1 receptors, is a potent inhibitor of vagally stimulated acid secretion in adult rabbits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 00:48:59