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Titolo:
XENOGENIC TRANSPLANTATION OF MICROENCAPSULATED HEPATOCYTES - UREAGENESIS OF RETRIEVED ENCAPSULATED HEPATOCYTES
Autore:
KHAN AA; HABIBULLAH CM; AYESHA Q; LAHIRI S;
Indirizzi:
OSMANIA GEN HOSP,DEPT GASTROENTEROL HYDERABAD 12 ANDHRA PRADESH INDIA OSMANIA GEN HOSP,DEPT GASTROENTEROL HYDERABAD 12 ANDHRA PRADESH INDIA
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 4, volume: 4, anno: 1995,
pagine: 183 - 189
SICI:
1386-6346(1995)4:4<183:XTOMH->2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROCARRIER-ATTACHED HEPATOCYTES; LIVER-FUNCTION; GUNN-RATS; CELLS; MICROCAPSULES; SURVIVAL; PANCREAS; ISLETS;
Keywords:
TRANSPLANTATION; MICROENCAPSULATION; UREAGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Khan et al., "XENOGENIC TRANSPLANTATION OF MICROENCAPSULATED HEPATOCYTES - UREAGENESIS OF RETRIEVED ENCAPSULATED HEPATOCYTES", HEPATOLOGY RESEARCH, 4(4), 1995, pp. 183-189

Abstract

The microencapsulation technique is being used successfully in various types of cells for providing a substratum for long-term survival andimmunoprotection to immobilized transplanted cells. Rat hepatocytes were microencapsulated in alginic acid poly-l-lysine membrane and transplanted intraperitoneally in rabbits. The animals were followed up to study the functional capacity of transplanted hepatocytes by assessingureagenesis and the efficacy of the capsule membrane to provide a physical barrier between the host's immune system and the encapsulated hepatocytes, assessed by no evidence of hepatocyte rejection by the hostfor up to 2 months, The transplanted animals were sacrificed by cervical dislocation after 15, 30, 45 and 60 days. The transplanted capsules were retrieved and the hepatocytes were studied for their capacity for ureagenesis. The capsules were found intact even after 60 days of transplantation. The retrieval was 75% with 80% of viable cells displaying normal functional capacity to produce urea. Therefore, it may be concluded that the microencapsulation technique is effective in maintaining functional capacity and providing a physical barrier between the host's immune system and immobilized cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 14:32:42