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Titolo:
PLASMA HALOPERIDOL AND REDUCED HALOPERIDOL CONCENTRATIONS IN A GERIATRIC POPULATION
Autore:
CHANG WH; JANN MW; CHIANG TS; LIN HN; HU WH; CHIEN CP;
Indirizzi:
TAIPEI CITY PSYCHIAT CTR,LAB BIOL PSYCHIAT,309 SUNG TE RD TAIPEI 10510 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT PSYCHIAT TAIPEI TAIWAN TAIPEI MUNICIPAL KWANGTZU PO AI TAIPEI TAIWAN MERCER UNIV,SO SCH PHARM MACON GA 31207
Titolo Testata:
Neuropsychobiology
fascicolo: 1, volume: 33, anno: 1996,
pagine: 12 - 16
SICI:
0302-282X(1996)33:1<12:PHARHC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE HYDROXYLATION PHENOTYPE; PHARMACOKINETICS; DISPOSITION;
Keywords:
HALOPERIDOL; REDUCED HALOPERIDOL; PLASMA LEVELS; GERIATRICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
W.H. Chang et al., "PLASMA HALOPERIDOL AND REDUCED HALOPERIDOL CONCENTRATIONS IN A GERIATRIC POPULATION", Neuropsychobiology, 33(1), 1996, pp. 12-16

Abstract

Haloperidol (HL) and reduced haloperidol (RH) plasma concentrations were measured in geriatric patients (n = 45) and schizophrenic patients(n = 8). In the elderly patients, HL doses were 1-4 mg/day while only2 mg/day was used in the schizophrenics. At HL 2 mg/day dose in both age groups, mean plasma HL levels were approximately twice as high in the elderly patients compared to the schizophrenics(1.39 +/- 0.82 vs. 0.56 +/- 0.23 ng/ml, p < 0.02). RH plasma concentrations were almost 5times greater in the elderly patients (0.54 +/- 0.35 vs. 0.09 +/- 0.05 ng/ml, p < 0.0001). These results suggest that HL plasma concentrations in the elderly are greater than in adult schizophrenic patients treated with similiar HL doses.

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Documento generato il 05/04/20 alle ore 22:44:03