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Titolo:
THE GUANYLYL CYCLASE CORE OF AN ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR -ENZYMATIC-PROPERTIES AND BASIS FOR COOPERATIVITY
Autore:
THORPE DS; NIU S; MORKIN E;
Indirizzi:
SELECTIDE CORP,DEPT DISCOVERY BIOL,1580 E HANLEY BLVD TUCSON AZ 85737 UNIV ARIZONA,COLL MED,ARIZONA HLTH SCI CTR,DEPT PHYSIOL TUCSON AZ 85724 UNIV ARIZONA,COLL MED,ARIZONA HLTH SCI CTR,DEPT INTERNAL MED TUCSON AZ 85724 UNIV ARIZONA,COLL MED,ARIZONA HLTH SCI CTR,UNIV HEART CTR TUCSON AZ 85724
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 218, anno: 1996,
pagine: 670 - 673
SICI:
0006-291X(1996)218:3<670:TGCCOA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Thorpe et al., "THE GUANYLYL CYCLASE CORE OF AN ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR -ENZYMATIC-PROPERTIES AND BASIS FOR COOPERATIVITY", Biochemical and biophysical research communications, 218(3), 1996, pp. 670-673

Abstract

The enzymatic properties of a cloned atrial natriuretic peptide receptor are described. The renatured catalytic core had maximal activity with Mn2+, and all nucleoside triphosphates inhibited the enzyme competitively. The catalytic specificity of the enzyme was tested directly. The cyclase reaction was specific for guanine, producing cGMP and cyclic deoxyGMP. Surprisingly, deoxyguanylyl cyclase kinetics were classical, unlike the positive cooperativity seen for guanylyl cyclase activity, suggesting that the 2' hydroxyl group of GTP is necessary for the allosteric mechanism. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:00:49