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Titolo:
LATERAL PARABRACHIAL NUCLEUS AND SEROTONERGIC MECHANISMS IN THE CONTROL OF SALT APPETITE IN RATS
Autore:
MENANI JV; THUNHORST RL; JOHNSON AK;
Indirizzi:
UNIV IOWA,DEPT PSYCHOL,11 SEASHORE HALL E IOWA CITY IA 52242 UNIV IOWA,DEPT PHARMACOL IOWA CITY IA 52242 UNIV IOWA,CTR CARDIOVASC IOWA CITY IA 52242 PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 1, volume: 39, anno: 1996,
pagine: 162 - 168
SICI:
0363-6119(1996)39:1<162:LPNASM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM APPETITE; SOLITARY TRACT; AREA POSTREMA; ANGIOTENSIN-II; EFFERENT CONNECTIONS; DRINKING; LESIONS; HYPOVOLEMIA; WATER; RENIN;
Keywords:
ANGIOTENSIN II; WATER INTAKE; SALT INTAKE; FUROSEMIDE; SODIUM CHLORIDE INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.V. Menani et al., "LATERAL PARABRACHIAL NUCLEUS AND SEROTONERGIC MECHANISMS IN THE CONTROL OF SALT APPETITE IN RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 39(1), 1996, pp. 162-168

Abstract

This study investigated the effects of bilateral injections of serotonergic receptor agonist and antagonist into the lateral parabrachial nucleus (LPBN) on the ingestion of water and 0.3 M NaCl induced by intracerebroventricular angiotensin II (ANG II) or by combined subcutaneous injections of the diuretic furosemide (Furo) and the angiotensin-converting enzyme inhibitor captopril (Cap). Rats had stainless steel cannulas implanted bilaterally into the LPBN and into the left lateral ventricle. Bilateral LPBN pretreatment with the serotonergic 5-HT1/5-HT2receptor antagonist methysergide (4 mu g/200 nl each site) increased 0.3 M NaCl and water intakes induced by intracerebroventricular ANG II(50 ng/mu l) and 0.3 M NaCl intake induced by subcutaneous Furo + Cap. Pretreatment with bilateral LPBN injections of a serotonergic 5-HT2A/2C receptor agonist DOI (5 mu g/200 nl) significantly reduced 0.3 M NaCl intake induced by subcutaneous Furo + Cap. Pretreatment with methysergide or DOI into the LPBN produced no significant changes in the water intake induced by subcutaneous Furo + Cap. These results suggest that serotonergic mechanisms associated with the LPBN may have inhibitory roles in water and sodium ingestion in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:45:00