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Titolo:
[I-123] IBZM SPECT FOR IMAGING OF STRIATAL D-2 DOPAMINE-RECEPTORS IN 56 SCHIZOPHRENIC-PATIENTS TAKING VARIOUS NEUROLEPTICS
Autore:
KLEMM E; GRUNWALD F; KASPER S; MENZEL C; BROICH K; DANOS P; REICHMANN K; KRAPPEL C; RIEKER O; BRIELE B; HOTZE AL; MOLLER HJ; BIERSACK HJ;
Indirizzi:
UNIV BONN,DEPT NUCL MED,SIGMUND FREUD STR 25 D-53105 BONN GERMANY UNIV BONN,DEPT PSYCHIAT D-53105 BONN GERMANY
Titolo Testata:
The American journal of psychiatry
fascicolo: 2, volume: 153, anno: 1996,
pagine: 183 - 190
SICI:
0002-953X(1996)153:2<183:[ISFIO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; D2 DOPAMINE; HUMAN-BRAIN; ANTIPSYCHOTIC-DRUGS; INVITRO BINDING; CLOZAPINE; OCCUPANCY; HALOPERIDOL; BLOCKADE; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
E. Klemm et al., "[I-123] IBZM SPECT FOR IMAGING OF STRIATAL D-2 DOPAMINE-RECEPTORS IN 56 SCHIZOPHRENIC-PATIENTS TAKING VARIOUS NEUROLEPTICS", The American journal of psychiatry, 153(2), 1996, pp. 183-190

Abstract

Objective: The purpose of this study was to compare the binding of various typical and atypical neuroleptics to striatal D-2 dopamine receptors in schizophrenic patients. Method: Fifty-six inpatients with schizophrenia, including 14 with schizoaffective disorder and one with schizophreniform disorder, were evaluated. Fourteen patients were neuroleptic free. Single photon emission computed tomography (SPECT) was performed 90 minutes after intravenous injection of [I-123]benzamide ([I-123]IBZM). Subsequent semiquantitative analysis of D-2 receptor bindingwas done with the use of the basal ganglia (striatum)/frontal cortex (BG/FC) ratio of activity. Clinical symptoms were rated with the Positive and Negative Syndrome Scale and the Hamilton Depression Rating Scale. Results: The BG/FC ratios in patients taking typical neuroleptics were significantly lower than those in the neuroleptic-free subjects but not lower than those in the patients taking atypical neuroleptics (clozapine, remoxipride). For atypical antipsychotics, a dose-dependentrelationship with striatal D-2 receptor binding could not be demonstrated. BG/FC ratios were not significantly correlated with clinical symptoms or with duration of illness. Conclusions: The results indicate that [I-123]IBZM SPECT is useful for semiquantitative imaging of striatal D-2 dopamine receptors and for estimating their blockade by neuroleptics. Thus, it may improve drug monitoring in psychiatric patients. Furthermore, the findings suggest a complex relationship between the antipsychotic effect of atypical neuroleptics and D-2 receptor blockade.

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Documento generato il 18/01/20 alle ore 11:00:18