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Titolo:
A POTENTIAL CONTRIBUTION TO ETHANOL WITHDRAWAL KINDLING - REDUCED GABA FUNCTION IN THE INFERIOR COLLICULAR CORTEX
Autore:
MCCOWN TJ; BREESE GR;
Indirizzi:
UNIV N CAROLINA,BRAIN & DEV RES CTR 223,CAMPUS BOX 7250 CHAPEL HILL NC 27599 UNIV N CAROLINA,DEPT PHARMACOL CHAPEL HILL NC 27599 UNIV N CAROLINA,DEPT PSYCHIAT CHAPEL HILL NC 27599 UNIV N CAROLINA,CTR ALCOHOL STUDIES CHAPEL HILL NC 00000
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 6, volume: 17, anno: 1993,
pagine: 1290 - 1294
SICI:
0145-6008(1993)17:6<1290:APCTEW>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHYSICAL-DEPENDENCE; SEIZURE ACTIVITY; SITE; RAT; INTOXICATION; INHIBITION; GENESIS; COMPLEX;
Keywords:
ETHANOL WITHDRAWAL; KINDLING; INFERIOR COLLICULAR CORTEX; GABA; NMDA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Mccown e G.R. Breese, "A POTENTIAL CONTRIBUTION TO ETHANOL WITHDRAWAL KINDLING - REDUCED GABA FUNCTION IN THE INFERIOR COLLICULAR CORTEX", Alcoholism, clinical and experimental research, 17(6), 1993, pp. 1290-1294

Abstract

Because multiple withdrawals from chronic ethanol treatment facilitate the rate of kindling from the inferior collicular cortex, the following studies sought to identify potential sources of this long-term change in seizure sensitivity. When rats received 6 or 10 withdrawals from a 5-day ethanol liquid diet, a significant decrease was found in thethreshold frequency for seizure genesis, 6-7 days postwithdrawal. Themagnitude of this change was related to the number of withdrawals (6 withdrawals, -2.0 +/- 0.3 Hz; 10 withdrawals, -3.2 +/- 1.2 Hz). Thus, multiple ethanol withdrawals increased seizure sensitivity within the inferior collicular cortex. On the following day in the same animals, changes in inhibitory or excitatory function were evaluated within theinferior collicular cortex. We found a withdrawal-related increase inthe effectiveness of bicuculline to reduce the seizure threshold current within the inferior collicular cortex. Seizure sensitivity to collicular N-methyl-D-aspartic acid (NMDA) microinjection was decreased after 6 ethanol withdrawals, and increased after 10 withdrawals, but control liquid diet animals exhibited similar responses to collicular NMDA microinjection. Therefore, multiple withdrawals from ethanol alters the seizure sensitivity within the inferior collicular cortex. One possible contribution to this change is a local decrease in GABA inhibitory function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 12:18:55