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Titolo:
THE INCREASE IN GROWTH-HORMONE SECRETION IN EXPERIMENTALLY-INDUCED ARTHRITIC RATS IS AN ADAPTIVE PROCESS INVOLVED IN THE REGULATION OF INFLAMMATION
Autore:
BLUETPAJOT MT; MOUNIER F; SLAMA A; VIDEAU C; KORDON C; EPELBAUM J; CALVINO B;
Indirizzi:
INSERM,U159,2TER RUE ALESIA F-75014 PARIS FRANCE FAC MED,U421 INSERM CRETEIL FRANCE
Titolo Testata:
Neuroendocrinology
fascicolo: 1, volume: 63, anno: 1996,
pagine: 85 - 92
SICI:
0028-3835(1996)63:1<85:TIIGSI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADJUVANT-INDUCED ARTHRITIS; ANTERIOR-PITUITARY CELLS; GH-RELEASING HORMONE; MESSENGER-RNA LEVELS; CHRONIC PAIN; SUBSTANCE-P; SOMATOSTATIN NEURONS; MONOSODIUM GLUTAMATE; PROLACTIN; BINDING;
Keywords:
ULTRADIAN RHYTHM; MONOSODIUM GLUTAMATE; ARTHRITIS, FREUND-ADJUVANT-INDUCED; CLONIDINE; GROWTH HORMONE; GROWTH-HORMONE-RELEASING HORMONE; NEUROIMMUNE INTERACTIONS; SOMATOSTATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Bluetpajot et al., "THE INCREASE IN GROWTH-HORMONE SECRETION IN EXPERIMENTALLY-INDUCED ARTHRITIC RATS IS AN ADAPTIVE PROCESS INVOLVED IN THE REGULATION OF INFLAMMATION", Neuroendocrinology, 63(1), 1996, pp. 85-92

Abstract

In Sprague-Dawley rats, Freund-adjuvant-induced arthritis (AIA) results in an increase in the amplitude of ultradian growth-hormone (GH)-secretory episodes without modification of their frequency. This is mostapparent at the time of maximal inflammation, i.e. 14-21 days after inoculation of the adjuvant. GH responsiveness to a maximal dose of clonidine (10 mu g/100 g body weight, BW), a secretagogue known to act atthe hypothalamic level, is comparable in AIA and control rats. In contrast, GH response to a maximal dose of GH-releasing hormone(GHRH, 1 mu g/100 g BW), a peptide acting directly on pituitary somatotropes, isgreater in AIA than in control rats. Furthermore AIA affects significantly neither hypothalamic somatostatin and GHRH mRNA levels nor pituitary GH content. In adult rats treated neonatally with monosodium glutamate (MSG), a neurotoxin which destroys the majority of GHRH neurons of the arcuate nucleus and reduces considerably plasma GH levels, clinical symptoms observed 14 days after inoculation of the Freund adjuvant are more marked than in AIA. The MSG-treated rats exhibit in particular a significantly higher increase in hindpaw diameter. Pulsatile administration of GH (40 mu g/day/rat, with successive periods of 2 h of GH and 4 h of mineral oil) restoring the endogenous GH-secretory pattern throughout the 15-day period of arthritis development prevents hindpaw diameter increase. These results indicate that the impact of AIA on GH regulation occurs at the pituitary but not the hypothalamic leveland suggest that increased GH secretion observed in AIA rats is an adaptive mechanism involved in the regulation of the inflammatory process.

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Documento generato il 02/04/20 alle ore 02:57:22