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Titolo:
MULTIPLE IMMUNE ABNORMALITIES IN TUMOR-NECROSIS-FACTOR AND LYMPHOTOXIN-ALPHA DOUBLE-DEFICIENT MICE
Autore:
EUGSTER HP; MULLER M; KARRER U; CAR BD; SCHNYDER B; ENG VM; WOERLY G; LEHIR M; DIPADOVA F; AGUET M; ZINKERNAGEL R; BLUETHMANN H; RYFFEL B;
Indirizzi:
ETH ZURICH,INST TOXICOL,SCHORENSTR 16 CH-8603 SCHWERZENBACH SWITZERLAND INST EXPTL IMMUNOL CH-8091 ZURICH SWITZERLAND SANDOZ LTD,PRECLIN RES CH-4002 BASEL SWITZERLAND F HOFFMANN LA ROCHE & CO LTD,PHARMACEUT RES GENE TECHNOL CH-4002 BASEL SWITZERLAND
Titolo Testata:
International immunology
fascicolo: 1, volume: 8, anno: 1996,
pagine: 23 - 36
SICI:
0953-8178(1996)8:1<23:MIAITA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I GENES; FACTOR RECEPTOR; TNF-ALPHA; LISTERIA-MONOCYTOGENES; T-CELLS; BETA LYMPHOTOXIN; TRANSGENIC MICE; ENDOTOXIC-SHOCK; EXPRESSION; PROLIFERATION;
Keywords:
ALYMPHOPLASIA; ENDOTOXIC SHOCK; ISOTYPE SWITCH; LISTERIA; LYMPHOCYTOSIS; PEYERS PATCHES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
H.P. Eugster et al., "MULTIPLE IMMUNE ABNORMALITIES IN TUMOR-NECROSIS-FACTOR AND LYMPHOTOXIN-ALPHA DOUBLE-DEFICIENT MICE", International immunology, 8(1), 1996, pp. 23-36

Abstract

To investigate the roles of tumor necrosis factor (TNF) and lymphotoxin (LT)-alpha in the development and function of the immune system, the Tnf and Lt alpha genes were simultaneously inactivated in mice by homologous recombination, These mutant mice are highly susceptible to Listeria monocytogenes infection and resistant to endotoxic shock induced by the combined administration of D-galactosamine (D-GalN) and lipopolysaccharide (LPS), Their splenic microarchitecture is disorganized, characterized by the loss of the clearly defined marginal zone, ill defined T and a cell areas, and absence of MAdCAM-1 and reduced ICAM-1, VCAM-1 and Mac-1 expression. They are devoid of peripheral lymph nodesand Peyer's patches, and show a strong reduction of IgA(+) plasma cells in the intestinal lamina propria, The alymphoplasia is accompanied by a marked a lymphocytosis and reduced basal Ig levels, Ig depositions in the renal glomerulus and a strong up-regulation of MHC class I antigen expression on endothelial cells of different tissues are observed. The primary humoral immune response towards sheep red blood cells reveals a defective IgG isotype switch, while that against vescicular stomatitis virus is normal, The cytotoxic T cell responses are attenuated, although still effective, against vaccinia, lymphocytic choriomeningitis virus (LCMV-ARM) and LCMV-WE. In conclusion, the combined inactivation of Tnf and Lt alpha confirms their essential role in the normal development and function of the immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:02:26