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Titolo:
BIOLOGICAL AND CLINICOPATHOLOGICAL FEATURES ASSOCIATED WITH HEPATITIS-C VIRUS TYPE-5 INFECTIONS
Autore:
MURPHY DG; WILLEMS B; VINCELETTE J; BERNIER L; COTE J; DELAGE G;
Indirizzi:
LAB SANTE PUBL QUEBEC,20045 CHEMIN ST MARIE ST ANNE BELLEVUE PQ H9X 3R5 CANADA HOP ST LUC,SERV HEPATOL MONTREAL PQ H2X 1P1 CANADA HOP ST LUC,SERV MICROBIOL & MALAD INFECT MONTREAL PQ H2X 1P1 CANADA HOP ST LUC,SERV ANAT PATHOL MONTREAL PQ H2X 1P1 CANADA UNIV MONTREAL,DEPT MICROBIOL & IMMUNOL MONTREAL PQ H3C 3J7 CANADA
Titolo Testata:
Journal of hepatology
fascicolo: 1, volume: 24, anno: 1996,
pagine: 109 - 113
SICI:
0168-8278(1996)24:1<109:BACFAW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION;
Keywords:
GENOTYPE; HEPATITIS C VIRUS; QUANTITATIVE RT-PCR; SEROLOGICAL REACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Murphy et al., "BIOLOGICAL AND CLINICOPATHOLOGICAL FEATURES ASSOCIATED WITH HEPATITIS-C VIRUS TYPE-5 INFECTIONS", Journal of hepatology, 24(1), 1996, pp. 109-113

Abstract

Background/Aims: The biological and clinicopathological features of hepatitis C virus infections of type 1 and type 2 have been well documented. However, little is known about the nature of HCV type 5 infections, which have been found to occur in South Africa but rarely elsewhere. Methods: We investigated the HCV genotypes in 125 viremic blood donors and 125 viremic patients by restriction endonuclease analysis of amplified 5' noncoding region sequences. Donors and patients infected with type 5 were further studied. Serum HCV RNA levels were assessed bya differential-size PCR-aided transcript titration assay. Results: HCV type 5 infections were identified in seven (5.6%) of the blood donors and in five (4.0%) of the patients. Sera from these 12 persons reacted with the core and NS3 antigens in both RIBA-2 and RIBA-3 tests. Six(50%) and 10 (83%) sera reacted with the NS4 antigens in RIBA-2 and RIBA-3 tests, respectively. HCV type 5 was found to replicate to high titers that ranged from 10(6.0) to 10(8.0) molecules/ml. Transfusion was the most frequently observed risk factor (5 of 12) and persons infected with type 5 were generally older than those infected with other types (<40 years vs. greater than or equal to 40 years, p=0.01). Cirrhosis was found in two of six (33%) donors and three of four (75%) patients. The duration of infection appeared to be an important determinant for the presence of cirrhosis. Conclusions: In this small group of Canadians infected with HCV type 5, a high proportion developed severe liver disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:53:53