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Titolo:
SEIZURES DURING ALPHA-INTERFERON THERAPY
Autore:
SHAKIL AO; DIBISCEGLIE AM; HOOFNAGLE JH;
Indirizzi:
NIDDKD,DIGEST DIS BRANCH,LIVER DIS SECT,BLDG 31,ROOM 9A23,10 CTR DR,MSC 1372 BETHESDA MD 20892 NIDDKD,DIGEST DIS BRANCH,LIVER DIS SECT BETHESDA MD 20892
Titolo Testata:
Journal of hepatology
fascicolo: 1, volume: 24, anno: 1996,
pagine: 48 - 51
SICI:
0168-8278(1996)24:1<48:SDAT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEPATITIS-B; CONTROLLED TRIAL; ALFA THERAPY;
Keywords:
ALPHA INTERFERON; CHRONIC HEPATITIS; SEIZURES; SIDE-EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A.O. Shakil et al., "SEIZURES DURING ALPHA-INTERFERON THERAPY", Journal of hepatology, 24(1), 1996, pp. 48-51

Abstract

Background/Aims: Alpha interferon is now used widely in the therapy of chronic viral hepatitis. The common side effects of interferon are well known; the uncommon side effects are less well defined. We have evaluated the incidence and characteristics of seizures that occurred during alpha interferon therapy. Methods: A retrospective chart review was done on 311 patients with chronic hepatitis treated with alpha interferon between 1983 and 1994 at the National Institutes of Health. Results: Four of 311 patients (1.3%) developed grand mal seizures while on therapy with alpha interferon. Three patients had chronic hepatitis B (two had an accompanying glomerulonephritis) and one chronic delta hepatitis. Interferon had been given in doses of 5-10 million units each day or three times weekly for 2-14 months before the onset of seizures. No other obvious cause for seizures was identified. Seizures resolved once interferon was stopped, and did not recur even without chronic anticonvulsant therapy. Conclusions: Alpha interferon in the doses used to treat chronic viral hepatitis caused seizures in approximately 1% of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/06/20 alle ore 06:35:37