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Titolo:
EVIDENCE THAT GABA(A) BUT NOT GABA(B) RECEPTOR ACTIVATION IN THE DORSAL RAPHE NUCLEUS MODULATES ETHANOL INTAKE IN WISTAR RATS
Autore:
TOMKINS DM; FLETCHER PJ;
Indirizzi:
ADDICT RES FDN,33 RUSSELL ST TORONTO ON M5S 2S1 CANADA CLARKE INST PSYCHIAT,SECT BIOPSYCHOL TORONTO ON M5T 1R8 CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON CANADA
Titolo Testata:
Behavioural pharmacology
fascicolo: 1, volume: 7, anno: 1996,
pagine: 85 - 93
SICI:
0955-8810(1996)7:1<85:ETGBNG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABAERGIC AGONISTS; LABORATORY RATS; DEPRIVED RATS; ANTAGONISTS; STIMULATION; INVOLVEMENT; RO15-4513; MUSCIMOL; MICROINJECTIONS; TRANSMISSION;
Keywords:
BACLOFEN; BICUCULLINE; DORSAL RAPHE; ETHANOL; GABA; MUSCIMOL; RAT; TRIP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Tomkins e P.J. Fletcher, "EVIDENCE THAT GABA(A) BUT NOT GABA(B) RECEPTOR ACTIVATION IN THE DORSAL RAPHE NUCLEUS MODULATES ETHANOL INTAKE IN WISTAR RATS", Behavioural pharmacology, 7(1), 1996, pp. 85-93

Abstract

Injection of the GABA(A) agonist muscimol into the dorsal raphe nucleus produces a marked and selective increase in voluntary ethanol intake. The purpose of the present study was threefold: first, to demonstrate that the effect of muscimol on ethanol consumption is mediated by GABA(A) receptors; secondly, to test the generalizability of this effect by examining the effects of another GABA(A) agonist, THIP on ethanoldrinking; and finally, to examine whether GABA(B) receptors within the dorsal raphe also play a role in modifying voluntary ethanol consumption under the same experimental conditions. Rats were trained to drink a 12% ethanol solution in a limited access paradigm with water concurrently available. Muscimol (50 ng) injected into the dorsal raphe enhanced ethanol intake by at least 100%. Peripheral administration of the GABA(A) antagonist bicuculline (4 mg/kg), but not the 5-HT1A antagonist(+)-WAY100135 (1 and 3 mg/kg), antagonized the stimulatory effect of muscimol at a dose which, when administered alone, did not alter ethanol intake. This supports the suggestion that the effect of muscimol is mediated via GABA(A) receptors. This conclusion was further supported by the finding that another GABA(A) agonist, THIP (500 ng), also selectively increased ethanol intake in this paradigm. Injection of bicuculline (60 ng) into the dorsal raphe reduced ethanol intake, but alsoappeared to reduce water intake. Finally, intra-dorsal raphe injection of the GABA(B) agonist baclofen (62.5 and 125 ng) did not produce any change in ethanol or water consumption. Together, these findings suggest that enhancement of GABAergic activity in the dorsal raphe increased voluntary ethanol intake via activation of GABA(A) but not GABA(B)receptors.

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Documento generato il 14/07/20 alle ore 10:06:24