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Titolo:
PROPOFOL PRODUCES DIFFERENCES IN BEHAVIOR BUT NOT CHLORIDE CHANNEL FUNCTION BETWEEN SELECTED LINES OF MICE
Autore:
SIMPSON VJ; BLEDNOV Y;
Indirizzi:
CHILDRENS HOSP,DEPT ANESTHESIOL,1056 E 19TH AVE DENVER CO 80218 UNIV COLORADO,HLTH SCI CTR,DEPT ANESTHESIOL DENVER CO 00000 UNIV COLORADO,HLTH SCI CTR,DEPT PHARMACOL DENVER CO 00000
Titolo Testata:
Anesthesia and analgesia
fascicolo: 2, volume: 82, anno: 1996,
pagine: 327 - 331
SICI:
0003-2999(1996)82:2<327:PPDIBB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-SLEEP MICE; GAMMA-AMINOBUTYRIC-ACID; GABA-A RECEPTORS; LONG-SLEEP; ETHANOL SENSITIVITY; GENETIC-DIFFERENCES; XENOPUS OOCYTES; ALCOHOL; CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
V.J. Simpson e Y. Blednov, "PROPOFOL PRODUCES DIFFERENCES IN BEHAVIOR BUT NOT CHLORIDE CHANNEL FUNCTION BETWEEN SELECTED LINES OF MICE", Anesthesia and analgesia, 82(2), 1996, pp. 327-331

Abstract

We report differential central nervous system (CNS) sensitivity to propofol between Long Sleep (LS) and Short Sleep (SS) mice, selectively bred for their differential CNS sensitivity to ethanol. Intravenous propofol requirements for loss of righting reflex, or sleep time, were measured to define the extent of this sensitivity. LS mice slept approximately two times longer than SS mice at equal doses. Awakening plasmaand brain levels of the SS line were, respectively, two and three times that of the LS line (P < 0.0001). This suggests that the LS and SS sleep time difference is CNS mediated, and that propofol and ethanol may share common genes that determine anesthetic sensitivities. The ethanol effect may be at least partially mediated by gamma-aminobutyric acid-A (GABA,) receptor function. Propofol had no differential effect on GABA, receptor function, as measured by chloride flux in LS and SS brain microsac preparations. Either the GABA, receptor does not mediatepropofol sleep time, or qualitative differences cannot be demonstrated using Cl-36(-) uptake in brain membranes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:41:47