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Titolo:
3-DIMENSIONAL ANALYSIS OF GLUTATHIONE-S-TRANSFERASE PLACENTAL FORM-POSITIVE LESION DEVELOPMENT IN EARLY STAGES OF RAT HEPATOCARCINOGENESIS
Autore:
KATO T; IMAIDA K; OGAWA K; HESEGAWA R; SHIRAI T; TATEMATSU M;
Indirizzi:
NAGOYA CITY UNIV,SCH MED,DEPT PATHOL 1,1 KAWASUMI,MIZUHO CHO,MIZUHO KU NAGOYA AICHI 467 JAPAN AICHI CANC CTR,RES INST,PATHOL LAB,CHIKUSA KU NAGOYA AICHI 464 JAPAN
Titolo Testata:
Japanese journal of cancer research
fascicolo: 12, volume: 84, anno: 1993,
pagine: 1252 - 1257
SICI:
0910-5050(1993)84:12<1252:3AOGPF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYME-ALTERED FOCI; GST-P; CHEMICAL HEPATOCARCINOGENESIS; QUANTITATIVE STEREOLOGY; HEPATOCELLULAR FOCI; LIVER; INDUCTION; MARKER; DIETHYLNITROSAMINE; PRENEOPLASIA;
Keywords:
RAT LIVER; PRENEOPLASTIC LESION; 3-DIMENSIONAL ANALYSIS; GLUTATHIONE S-TRANSFERASE PLACENTAL FORM; ENZYME-ALTERED FOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T. Kato et al., "3-DIMENSIONAL ANALYSIS OF GLUTATHIONE-S-TRANSFERASE PLACENTAL FORM-POSITIVE LESION DEVELOPMENT IN EARLY STAGES OF RAT HEPATOCARCINOGENESIS", Japanese journal of cancer research, 84(12), 1993, pp. 1252-1257

Abstract

The development of glutathione S-transferase placental form (GST-P)-positive lesions in the rat liver, from single cells to foci, and theirlocations within liver lobules were examined by a combined stereological approach for calculation of three-dimensional (3-D) data and by 3-D computer graphics for reconstruction of lesions. Two weeks after initiation with diethylnitrosamine, the rats were divided into two groups. Animals in group 1 were given 2-acetylaminofluorene, and animals in group 2 were given basal diet for 6 weeks. Partial hepatectomy (PH) was performed at week 3. The GST-P-positive single cells increased in number per liver after PH in group 1, but not in group 2, where a plateau level was maintained. The number of GST-P-positive foci per liver ingroup 2 also reached an almost constant low value after 4 weeks. In contrast, foci in group 1 increased greatly after PH. A 3-D reconstruction, performed with a computer graphics system using up to 180 sections at 10 mum intervals, revealed the single cells to be distributed at random. Those that grew into foci were also not preferentially localized in any particular zone of the hepatic lobule. When foci within the same lobule came into contact, they underwent fusion. The present results thus indicate that only a small proportion of GST-P-positive single cells develops into foci, and that their growth is independent of zonal factors within individual lobules in early stages of rat hepatocarcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 04:00:16