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Titolo:
SEROTONIN REUPTAKE INHIBITORS REDUCE CONDITIONED FEAR STRESS-INDUCED FREEZING BEHAVIOR IN RATS
Autore:
HASHIMOTO S; INOUE T; KOYAMA T;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PSYCHIAT,KITA KU,NORTH 15 WEST 7 SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 123, anno: 1996,
pagine: 182 - 186
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANXIETY; ANTIDEPRESSANTS; DIAZEPAM; ANXIOLYTICS; METABOLISM; IMIPRAMINE; FOOTSHOCK; DISORDERS; INCREASE; DRUGS;
Keywords:
ANXIETY; CONDITIONED FEAR STRESS; FREEZING BEHAVIOR; SEROTONIN REUPTAKE INHIBITORS; CITALOPRAM; FLUVOXAMINE; MILNACIPRAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S. Hashimoto et al., "SEROTONIN REUPTAKE INHIBITORS REDUCE CONDITIONED FEAR STRESS-INDUCED FREEZING BEHAVIOR IN RATS", Psychopharmacology, 123(2), 1996, pp. 182-186

Abstract

Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety. In the present study, freezing wasused to determine the anxiolytic activity of selective serotonin reuptake inhibitors (SSRIs), which are reported to be clinically effectivein anxiety disorders. The duration of freezing behavior was reduced by acute treatment with the SSRIs citalopram (1-10 mg/kg) and fluvoxamine (3-30 mg/kg). Acute treatment with the serotonin (5-HT) /noradrenaline (NA) mixed reuptake inhibitor milnacipran (3-30 mg/kg) also attenuated CFS-induced freezing, while acute treatment with the NA reuptake inhibitors maprotiline and ORG4428, and the dopamine (DA) reuptake inhibitor GBR12909 failed to alter CFS-induced freezing. These results indicate that facilitation of 5-HT availability in the brain produced by5-HT reuptake inhibition reduces CFS-induced freezing behavior. CFS may be a useful model for detecting the anxiolytic potential of 5-HT reuptake inhibitors.

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Documento generato il 28/09/20 alle ore 18:42:40