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Titolo:
MANGANESE TOXICITY, DOPAMINERGIC DYSFUNCTION AND HEPATIC-ENCEPHALOPATHY
Autore:
BUTTERWORTH RF; SPAHR L; FONTAINE S; LAYRARGUES GP;
Indirizzi:
UNIV MONTREAL,NEUROSCI RES UNIT,HOP ST LUC,1058 ST DENIS MONTREAL PQ H2X 3J4 CANADA UNIV MONTREAL,LIVER UNIT,HOP ST LUC MONTREAL PQ H2X 3J4 CANADA UNIV MONTREAL,DEPT RADIOL,HOP ST LUC MONTREAL PQ H2X 3J4 CANADA
Titolo Testata:
Metabolic brain disease
fascicolo: 4, volume: 10, anno: 1995,
pagine: 259 - 267
SICI:
0885-7490(1995)10:4<259:MTDDAH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOPSIED BRAIN-TISSUE; CEREBRAL BLOOD-FLOW; CIRRHOTIC-PATIENTS; BASAL GANGLIA; RAT-BRAIN; SIGNAL INTENSITY; LIVER-DISEASE; METABOLISM; CHLORIDE;
Keywords:
MANGANESE; HEPATIC ENCEPHALOPATHY; MR SIGNAL HYPERINTENSITY; GLOBUS PALLIDUS; DOPAMINE D-2 RECEPTORS; MAO; EXTRAPYRAMIDAL SYMPTOMS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R.F. Butterworth et al., "MANGANESE TOXICITY, DOPAMINERGIC DYSFUNCTION AND HEPATIC-ENCEPHALOPATHY", Metabolic brain disease, 10(4), 1995, pp. 259-267

Abstract

Patients with chronic liver disease manifest a high incidence (>75%) of pallidal signal hyperintensity on T-1-weighted Magnetic Resonance Imaging (MRI), the intensity of which correlates with blood manganese levels and the presence of extrapyramidal symptoms. A major cause of pallidal hyperintensity on T-1-weighted MRI is manganese deposition; chronic manganese intoxication in the absence of liver disease results inpallidal MR signal hyperintensity, in extrapyramidal symptoms and in selective effects on the dopaminergic neurotransmitter system in basalganglia. Direct measurements in globus pallidus obtained at autopsy from patients with chronic liver disease who died in hepatic coma reveal 2 to 7-fold increases of pallidal manganese and a concomitant loss of dopamine D-2 binding sites. Liver transplantation results in normalization of pallidal MR signals and of blood manganese levels. These findings suggest that (1) pallidal MR signal hyperintensity in patients with chronic liver disease is the result of manganese deposition and (2) alterations of dopaminergic function due to the toxic effects of manganese may contribute to the extrapyramidal symptoms in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:24:29