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Titolo:
PIPERASTATIN-A, A NEW SELECTIVE SERINE CARBOXYPEPTIDASE INHIBITOR PRODUCED BY ACTINOMYCETE .1. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES
Autore:
MURAKAMI S; HARADA S; YAMAZAKI T; TAKAHASHI Y; HAMADA M; TAKEUCHI T; AOYAGI T;
Indirizzi:
INST MICROBIAL CHEM,SINAGAWA KU,3-14-23 KAMIOSAKI TOKYO 141 JAPAN INST MICROBIAL CHEM,SINAGAWA KU TOKYO 141 JAPAN SHOWA COLL PHARMACEUT SCI MACHIDA TOKYO 194 JAPAN
Titolo Testata:
Journal of enzyme inhibition
fascicolo: 2, volume: 10, anno: 1996,
pagine: 93 - 103
SICI:
8755-5093(1996)10:2<93:PANSSC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT URINE; PLATELETS; HISTARGIN; ENZYME;
Keywords:
SERINE CARBOXYPEPTIDASE; CARBOXYPEPTIDASE Y; ENZYME INHIBITOR; PEPTIDE; ACTINOMYCETE; NATURAL COMPOUND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
S. Murakami et al., "PIPERASTATIN-A, A NEW SELECTIVE SERINE CARBOXYPEPTIDASE INHIBITOR PRODUCED BY ACTINOMYCETE .1. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES", Journal of enzyme inhibition, 10(2), 1996, pp. 93-103

Abstract

Piperastatin A (structure, N-formyl-allo Ile-Thr-Leu-Val-Pip-Leu-Pip,Pip = hexahydropyridadine-3-carboxylic acid; molecular weight, 809), a new inhibitor of serine carboxypeptidase was discovered in the fermentation broth of Streptomyces lavendofoliae MJ908-WF13. It was purified by activated charcoal chromatography, YMC gel ODS-A chromatograpy and centrifugal partition chromatography (CPC) by monitoring its inhibitory activity against carboxypeptidase Y (CP Y), and finally obtained as colourless needles. Piperastatin A is a competitive inhibitor of theenzyme with K-i = 52 +/- 6.2 nM. Piperastatin A is a highly specific inhibitor of the serine carboxypeptidases, CP-Y and platelet deamidasewith little effect on related enzymes, has no antimicrobial activity and has low toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:53:10