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Titolo:
PROSPECTIVE EVALUATION OF A CHAMOMILE MOUTHWASH FOR PREVENTION OF 5-FU-INDUCED ORAL MUCOSITIS
Autore:
FIDLER P; LOPRINZI CL; OFALLON JR; LEITCH JM; LEE JK; HAYES DL; NOVOTNY P; CLEMENSSCHUTJER D; BARTEL J; MICHALAK JC;
Indirizzi:
MAYO CLIN & MAYO FDN,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN ROCHESTER MN 55905 UNIV NEBRASKA MED CTR & ASSOCIATES,CREIGHTON UNIV,NEBRASKA ONCOL GRP OMAHA NE 00000 MERITCARE HOSP CCOP FARGO ND 00000 ILLINOIS ONCOL RES ASSOC,COMMUNITY CLIN ONCOL PROGRAM PEORIA IL 00000 IOWA ONCOL RES ASSOC,COMMUNITY CLIN ONCOL PROGRAM DES MOINES IA 00000 MERCY CANC CTR MASON CITY IA 00000 SASKATCHEWAN CANC FDN,ALLAN BLAIR MEM CLIN REGINA SK CANADA SIOUXLAND HEMATOL ONCOL ASSOCIATES SIOUX CITY IA 00000
Titolo Testata:
Cancer
fascicolo: 3, volume: 77, anno: 1996,
pagine: 522 - 525
SICI:
0008-543X(1996)77:3<522:PEOACM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED STOMATITIS; CRYOTHERAPY;
Keywords:
MUCOSITIS; STOMATITIS; CHAMOMILE; SYMPTOM CONTROL STUDY; CHEMOTHERAPY TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
P. Fidler et al., "PROSPECTIVE EVALUATION OF A CHAMOMILE MOUTHWASH FOR PREVENTION OF 5-FU-INDUCED ORAL MUCOSITIS", Cancer, 77(3), 1996, pp. 522-525

Abstract

BACKGROUND. Stomatitis has been found to be a major dose-limiting toxicity from bolus 5-fluorouracil-based (5-FU) chemotherapy regimens, despite the use of oral cryotherapy. Pursuant to preliminary data which suggested that a chamomile mouthwash might ameliorate this toxicity, aprospective trial was developed to test chamomile in this situation. METHODS. A Phase III, double-blind, placebo-controlled clinical trial was designed. Patients were entered into the study at the time of their first cycle of 5-FU-based chemotherapy. All patients received oral cryotherapy for 30 minutes with each dose of 5-FU. In addition, each patient was randomized to receive a chamomile or placebo mouthwash thrice daily for 14 days. Stomatitis scores were determined by health care providers and by patients themselves. RESULTS. There were 164 evaluable and well-stratified patients equally randomized to both treatment groups. There was no suggestion of any stomatitis difference between patients randomized to either protocol arm. There was also no suggestion of toxicity. Subset analysis did reveal unsuspected differential effects between males and females that could not be explained by reasons other than chance. CONCLUSION. The resultant data from this clinical trial did not support the prestudy hypothesis that chamomile could decrease 5-FU-induced stomatitis. (C) 1996 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:30:33