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Titolo:
RELAXIN SECRETION IN IN-VITRO FERTILIZATION PREGNANCIES
Autore:
HANING RV; GOLDSMITH LT; SEIFER DB; WHEELER C; FRISHMAN G; SARMENTO J; WEISS G;
Indirizzi:
BROWN UNIV,WOMEN & INFANTS HOSP,SCH MED,DEPT OBSTET & GYNECOL,101 DUDLEY ST PROVIDENCE RI 02905 BROWN UNIV,WOMEN & INFANTS HOSP,SCH MED,DEPT OBSTET & GYNECOL PROVIDENCE RI 02905 UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH NEWARK NJ 00000
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 1, volume: 174, anno: 1996,
parte:, 1
pagine: 233 - 240
SICI:
0002-9378(1996)174:1<233:RSIIFP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CORPUS-LUTEUM; OOCYTE DONATION; MENOPAUSAL WOMEN; PROGESTERONE;
Keywords:
RELAXIN; HUMAN CHORIONIC GONADOTROPIN; ESTRADIOL; PROGESTERONE; IN VITRO FERTILIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.V. Haning et al., "RELAXIN SECRETION IN IN-VITRO FERTILIZATION PREGNANCIES", American journal of obstetrics and gynecology, 174(1), 1996, pp. 233-240

Abstract

OBJECTIVE: This study was designed to determine whether the late luteal functional status of the corpora lutea in in vitro fertilization cycles alters the secretion of relaxin during pregnancy. STUDY DESIGN: Analysis of serum relaxin, human chorionic gonadotropin, and steroid concentrations in sera of women with pregnancies viable beyond the twelfth week as a result of in vitro fertilization treatment was performed. RESULTS: The serum estradiol and progesterone concentrations decreased 5.5- and 4-fold from days 5 to 6 after human chorionic gonadotropin to days 11 to 13 after human chorionic gonadotropin, respectively The serum relaxin concentration increased 8-fold between the 11- to 15-dayinterval and the 16- to 50-day interval after human chorionic gonadotropin and another 6-fold to the 51- to 90-day interval after human chorionic gonadotropin (all p < 0.01). Multiple linear regression analysis showed that the serum estradiol level 11 to 13 days after human chorionic gonadotropin and the serum human chorionic gonadotropin level 11to 15 days after human chorionic gonadotropin were the most powerful paired predictors of the concentration of serum relaxin measured in the 11- to 15-day interval after human chorionic gonadotropin interval (R(2)=0.39, n=50), the 16- to 50-day interval (R(2)-0.61, n=51), and the 51- to SD-day interval (R(2)=0.55, n=39). CONCLUSION: Secretion of relaxin is determined by an interaction of the late luteal functional status of the corpora lutea and the human chorionic gonadotropin secreted by the implanting pregnancy. These data allow for the hypothesis that inducing functional luteolysis by substituting one or more injections of luteinizing hormone for the human chorionic gonadotropin injection may decrease secretion of steroids, relaxin, and other factors fromthe corpora lutea during pregnancy, decreasing the risk of premature delivery in multiple gestations and the ovarian hyperstimulation syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:29:46